Noninvasive prenatal DNA test as a screening procedure for women from different risk groups: A view on the problem


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Abstract

Objective. To evaluate the efficiency of a noninvasive prenatal test (NIPT) to identify chromosomal anomalies in maternal blood samples. Material and methods. The review included the data of foreign and Russian articles published in the past 15 years and found in Pubmed on this topic. Results. This review gives the results of recent studies determining the sensitivity, specificity, and accuracy of the noninvasive prenatal DNA test versus conventional screening techniques for pregnant women. It sets forth leading obstetric societies’ viewpoints about the place of this screening technique in prenatal testing. Conclusion. NIPT is a promising prenatal screening technique for its clinical introduction, by complying with the legal norms.

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About the authors

Nana K. Tetruashvili

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tetrauly@mail.ru
Doctor of Medicine, Head of the Department of Pregnancy Loss Prevention and Therapy

Lyudmila V. Kim

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kimika@list.ru
Graduate student, Department of Pregnancy Loss Prevention and Therapy

Nane G. Parsadanyan

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: nnnpars@mail.ru
Candidate of Medicine, obstetrician-gynecologist, Department of Pregnancy Loss Prevention and Therapy

Nataliy I. Fedorova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: natasha_fedorova@mail.ru
candidate of Medicine, obstetrician-gynecologist

I. Yu Barkov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Ekaterina S. Shubina

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_shubina@oparina4.ru
Graduate student, laboratory of molecular genetic methods

Dmitrii Y. Trofimov

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: d_trofimov@oparina4.ru
Ph.D. in medical sciences, Head of Laboratory of molecular genetic methods

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