RESULTS OF COMBINATION TREATMENT IN REPRODUCTIVE-AGED PATIENTS WITH HYSTEROMYOMA ACCOMPANIED BY MENORRHAGIAS


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Abstract

What management tactics should be for reproductive-aged patients with hysteromyoma accompanied by menorrhagias also remains relevant at the present time. Objective. To enhance the efficiency of combination treatment in reproductive-aged patients with hysteromyoma accompanied by menorrhagias and anemia. Subjects and methods. The investigation enrolled 55 reproductive-aged women with hysteromyoma accompanied by menorrhagias and anemia. A study group (Group 1) comprised 30 patients who were preoperatively treated with ulipristal acetate in combination with iron-containing drugs for 3 months and then underwent myomectomy. A control group (Group 2) included 25 patients who underwent surgery (myomectomy) with no previous drug therapy. Results. Three months after starting medical therapy, all the patients in Group 1 stopped menstruating completely. The size of myomatous nodules and uterus significantly decreased in Group 1. There was a statistically significant elevation in the level of hemoglobin in 100% of the women in the study group (p <0.01). Laparoscopic myomectomy was performed in both groups. Total intraoperative blood loss and the duration of surgery were found to reduce in Group 1. There was a decreased postoperative length of hospital stay. Conclusion. The use of ulipristal acetate in combination with iron-containing drugs is effective for preoperative preparation for reconstructive plastic intervention in reproductive-aged patients with hysteromyoma accompanied by menorrhagias and anemia.

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About the authors

Zarina V. Revazova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: atias@bk.ru
graduate student Moscow 117997, Ac. Oparina str. 4, Russia

Leila V. Adamyan

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; Moscow State Medical and Dental University

Email: adamyanleila@gmail.com
member of RAS, Doctor of Medicine, Professor, Deputy Director for Science; Honored Scientist of Russia; main specialist in obstetrics and gynecology of the Ministry of Health of Russia; Head of the Department of Reproductive Medicine and Surgery, Faculty of Postgraduate Education Moscow 117997, Ac. Oparina str. 4, Russia

Andrey V. Kozachenko

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_kozachenko@oparina4.ru
MD, leading researcher Moscow 117997, Ac. Oparina str. 4, Russia

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