THE VALUE OF ANTI-MÜLLERIAN HORMONE IN THE DIAGNOSIS OF POLYCYSTIC OVARY SYNDROME


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Abstract

Objective. To estimate the value of anti-Müllerian hormone (AMH) for the diagnosis of polycystic ovary syndrome (PCOS) and the possible characteristics of its secretion in various phenotypes of the syndrome. Subjects and methods. The investigation enrolled 502 reproductive-aged women, including 250 patients aged 25.4±4.2 years (body mass index (BMI), 24.2±5.6 kg/m2) with PCOS and 252 women (aged 25,2±3,8years; BMI, 24.2±5.6 kg/m2) without reproductive dysfunction. Four phenotypes of the syndrome were identified using the Rotterdam criteria. Phenotypes A, B, C, and D were detected in 58, 10.4, 6.4, and 25.2% of the women, respectively. The investigators made complex clinical and laboratory examinations, including small pelvic ultrasound and a study of the androgen profile, AMH, luteinizing hormone, follicle-stimulating hormone, prolactin, and thyroid-stimulating hormone. Results. The mean serum AMH level in the healthy women and women with PCOS was 3.3±1.9 and15.8±10.2ng/ml, respectively (p < 0.05). The highest AMH level (17.9±11.6 ng/ml) was found in the women with phenotype A as compared with other phenotypes of the syndrome (p < 0.05). ROC analysis revealed that the threshold level of AMH for the diagnosis of PCOS was 5.2 ng/ml (an AUC of 0.97, a sensitivity of 95%, a specificity of 92%, and a confidence interval (CI)) of 95%). Conclusion. The AMH level exceeding 5.2 ng/ml can be considered as a threshold in the diagnosis of PCOS regardless of the phenotype of the syndrome. The elevated serum level of AMH is a more specific and sensitive diagnostic criterion for PCOS than enlarged ovaries.

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About the authors

A. A NAIDUKOVA

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: aleeshka@mail.ru
post-graduate, department of gynecological endocrinology Moscow 117997, Ac. Oparina str. 4, Russia

E. K KAPRINA

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

post-graduate department of gynecological endocrinology Moscow 117997, Ac. Oparina str. 4, Russia

T. Yu IVANETS

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: t_ivanetz@oparina4.ru
PhD, Head of Research and diagnostic laboratory Moscow 117997, Ac. Oparina str. 4, Russia

G. E CHERNUKHA

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: g_chernukha@oparina4.ru
a doctor of medical sciences, professor, head of department of Gynecological Endocrinology Moscow 117997, Ac. Oparina str. 4, Russia

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