Role of proand contrinsular factors in the development of obstetric pathology


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Abstract

Objective. To investigate the effects of pro- and contrinsular proteins in women with metabolic syndrome and in those with normal metabolism on the development of obstetric pathology. Subjects and methods. The prospective case-control study used an enzyme immunoassay technique to determine the serum levels of pro- and contrinsular factors (insulin-like growth factor-1, insulin-like growth factor-1 binding protein, receptor for glycation end products, and retinol-binding protein-4) in 150 patients with metabolic syndrome and 143 women with normal metabolism over time (1-3 trimesters). For data analysis, the investigators used descriptive statistics procedures that were employed to estimate the median values and interquartile ranges (25% to 75%). The significance level was set to be equal to 0.05. Results and discussion. In patients with preeclampsia in the presence of metabolic syndrome, the values of insulinlike growth factor-1 were established to progressively increase by the third trimester, which were significantly higher than in women with physiological pregnancy and in those with normal metabolism. At the same time, the levels of the receptor of glycation end products were, on the contrary, significantly higher in the examinees with normal metabolism and uncomplicated pregnancy. The findings are suggestive of the initiation of insulin resistance in women with metabolic syndrome in the early pregnancy periods and of endothelial dysfunction that is most obvious in patients with preeclampsia. Conclusion. Pregnant women with metabolic syndrome develop insulin resistance just in the first trimester. The decreased level of receptors for glycation end products in pregnant women with metabolic syndrome indicates the development of endothelial dysfunction that is most pronounced in patients with preeclampsia.

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About the authors

Viktor Anatolievich Linde

Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia

Email: vik-linde@yandex.ru
Professor, Doctor of Medicine, Director

Natalia Viktorovna Palieva

Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia

Email: nat-palieva@yandex.ru
Candidate of Medical Sciences, Academic Secretary

Tatiana Leonidovna Botasheva

Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia

Email: t_botasheva@mail.ru
Professor, Doctor of Medicine, Head of the Female Physiology Laboratory, Chief Researcher of the Obstetrics and Gynecology Department

Valeria Viktorovna Avrutskaya

Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia

Email: V.Avrutskaya@rniiap.ru
Doctor of Medicine, Chief Researcher of the Obstetrics and Gynecology Department

Maria Vasilievna Dudareva

Rostov Research Institute of Obstetrics and Pediatrics, Ministry of Health of Russia

Email: m.dudareva@rniiap.ru
Doctor of Biology, the Head of the clinic- diagnostic laboratory, the leading research assistant of Department of medical and biologic problems in obstetrics and pediatrics

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