The role of gene polymorphisms of the hemostatic system and folate cycle enzymes in the development of retrochorial hematoma
- Authors: Kuznetsova N.B.1, Bushtyreva I.O.1,2, Donnikov A.E.2, Mashkina E.V.3, Dybova V.S.4
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Affiliations:
- Rostov State Medical University
- Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
- Federal Autonomous Educational Institution of Higher Education the Southern Federal University
- Perinatal Center
- Issue: No 3 (2017)
- Pages: 62-67
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247932
- DOI: https://doi.org/10.18565/aig.2017.3.62-7
- ID: 247932
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Abstract
Objective. To assess the role of gene polymorphisms of the hemostatic system and folate cycle enzymes in the development of retrochorial hematoma (RCH). Subjects and methods. The investigation enrolled 305pregnant women who were examined and treated at the Rostov Regional Perinatal Center. All the pregnant women were divided into 2 groups: 1) 238pregnant women with RCH; 2) (a control group) 67 pregnant women with clinically normal pregnancy without RCH, as evidenced by first-trimester ultrasound. To identify genetic markers determining the development of chorion detachment, the pregnant women in the first-trimester underwent genotyping of four polymorphic loci of the folate cycle genes (MTHFR C677T, MTHFR A1298C, MTR А2756G, and MTRR А66С) and eight hemostatic genes (F2 G20210A, F5 G1691A, G10976A F7, F13 G103T, FGB G-455А, C807TITGA2, ITGB3 Т1565С, and SERPINE1-675 5G/4G). Results. Significant differences were obtained in a study of the distribution of the alleles G10976A of the F7 gene, G103T of the F13 gene, and G-455A of the FGB gene in a group of pregnant women with RCH versus that of pregnant women with clinically normal pregnancy. The A allele of F7 G10976A, the T allele F13 G103T, and the A allele of FGB G-455A were found to be associated with a high risk for RCH. Conclusion. The F7 gene (proconvertin, CF VII) polymorphism G10976A (rs 6046), the F13 gene (Fibrinase, CF XIII) G103T polymorphism (rs 5985), and the FGB gene (fibrinogen β-chain) polymorphism G-455A (rs 1800790) are associated with the risk of RCH.
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About the authors
Natalia Borisovna Kuznetsova
Rostov State Medical University
Email: lauranb@inbox.ru
Ph.D. in medical sciences, the assistant of the Department of Obstetrics, Gynecology and Reproduction № 4
Irina Olegovna Bushtyreva
Rostov State Medical University; Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: kio4@mail.ru
MD, Professor, the Head of the Department of Obstetrics, Gynecology and Reproduction № 4; leading researcher
Andrey Evgenievich Donnikov
Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: a_donnikov@oparina4.ru
Ph.D. in medical sciences, leading researcher of Laboratory of molecular genetic methods
Elena Vladimirovna Mashkina
Federal Autonomous Educational Institution of Higher Education the Southern Federal University
Email: lenmash@mail.ru
Ph.D. in biological sciences, the assistant of the genetics department
Violetta Sergeevna Dybova
Perinatal Center
Email: viola-kovaleva@mail.ru
obstetrician-gynecologist Rostov-on-Don
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