Characteristics of the phenotype of peripheral blood lymphocytes in women with idiopathic recurrent miscarriage in relation to the outcome of pregnancy during immunocytotherapy
- Authors: Krechetova L.V.1, Tetruashvili N.K.1, Vtorushina V.V.1, Nikolaeva M.A.1, Khachatryan N.A.1, Agadzhanova A.A.1, Vanko L.V1, Ivanets T.Y.1, Sukhikh G.T.1
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Affiliations:
- Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
- Issue: No 7 (2017)
- Pages: 52-60
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247952
- DOI: https://doi.org/10.18565/aig.2017.7.52-60
- ID: 247952
Cite item
Abstract
Full Text
About the authors
Lyubov V. Krechetova
Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: k_l_v_@mail.ru
Ph.D. in medical sciences, Head of Laboratory of Clinical Immunology
Nana K. Tetruashvili
Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: tetrauly@mail.ru
Doctor of Medicine, Head of the Department of Pregnancy Loss Prevention and Therapy
Valentina V. Vtorushina
Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: vtorushina@inbox.ru
Ph.D. in medical sciences, doctor of laboratory diagnostics in Laboratory of Clinical Immunology
Marina A. Nikolaeva
Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: nikolaeva_ma@mail.ru
Doctor of Science, Leading researcher, Laboratory of Clinical Immunology
Nelly A. Khachatryan
Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: nellyl986@mail.ru
Graduate student, Department of Pregnancy Loss Prevention and Therapy
Anna Aramovna Agadzhanova
Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: aagadjanova@mail.ru
Doctor of Medicine, Doctor of Department of Pregnancy Loss Prevention and Therapy
L. V Vanko
Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: l_Vanko@oparina4.ru
doctor of medicine, professor, leading research worker of clinical immunology laboratory
Tatiana Y. Ivanets
Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: t_ivanets@oparina4.ru
PhD. in medical sciences, Head of Clinical Diagnostic Laboratory
Gennady T. Sukhikh
Research Center of Obstetrics, Gynecology and Perinatology, Ministry of Health of RussiaMD, PhD, Academician of Russian Academy of Sciences, Professor, Director
References
- Carp Howard J.A., ed. Recurrent pregnancy loss: causes, controversies and treatment. Informa UK ltd.; 2007. 290p.
- Chong P.J., Matzner W.L., Ching W.T. Benefit of leukocyte immunizations? Fertil. Steril. 1993; 59(1): 247-9.
- Chong P.J., Matzner W.L., Ching W.T. Controversy about immunotherapy. Fertil. Steril. 1993; 59(5): 1138-9.
- Farquharson R.G., Stephenson M.D., eds. Early pregnancy. Cambridge: University Press; 2012. doi: http://dx.doi.org/10.1017/ CBO9780511777851. Available at: http://ebooks.cambridge.org/
- Сидельникова В.М., Сухих Г.Т. Невынашивание беременности. Руководство для практикующих врачей. М.: МИА; 2011. 516с.
- Loewendorf A., Nguyen T.A., Yesayan M.N., Kahn D.A. Normal human pregnancy results in maternal immune activation in the periphery and at the uteroplacental interface. PLoS One. 2014; 9(5): e96723.
- Посисеева Л.В., Малышкина А.И., Бойко Е.Л., Сотникова Н.Ю., Перетятко Л.П., Фетисова И.Н. Реабилитация репродуктивного здоровья супружеских пар с невынашиванием беременности. Иваново: «Изд-во Иваново»; 2008. 240с. [Posiseeva L.V., Malyshkina A.I., Boiko E.L., Sotnikova N.Y., Peretyatko L.P., Fetisova I.N. Rehabilitation of the reproductive health of married couples with recurrent pregnancy loss. Ivanovo: JSC Ivanovo; 2008. 240с. (in Russian)]
- Liang P., Mo M., Li G.G., Yin B., Cai J., Wu T. et al. Comprehensive analysis of peripheral blood lymphocytes in 76 women with recurrent miscarriage before and after lymphocyte immunotherapy. Am. J. Reprod. Immunol. 2012; 68(2): 164-74.
- Кречетова Л.В., Хачатрян Н.А., Тетруашвили Н.К., Вторушина В.В., Степанова Е.О., Николаева М.А., Сухих Г.Т. Особенности фенотипа лимфоцитов периферической крови женщин с привычным выкидышем. Акушерство и гинекология. 2014; 10: 27-32. [Krechetova L.V., Khachatryan N.A., Tetruashvili N.K., Vtorushina V.V., Stepanova E.O., Nikolaeva M.A., Sukhikh G.T. Specific features of peripheral blood lymphocyte phenotype in women with recurrent miscarriage. Akusherstvo i Ginekologiya/ Obstetrics and Gynecology. 2014; (10): 27-32. (in Russian)]
- Кречетова Л.В., Тетруашвили Н.К., Хачатрян Н.А., Вторушина В.В., Степанова Е.О., Николаева М.А., Сухих Г.Т. Диагностическая значимость оценки фенотипа лимфоцитов периферической крови женщин с привычным выкидышем. Акушерство и гинекология. 2015; 1: 25-31. [Krechetova L.V., Tetruashvili N.K., Khachatryan N.A., Vtorushina V.V., Stepanova E.O., Nikolaeva M.A., Sukhikh G.T. Diagnostic value of assessing a peripheral blood lymphocyte phenotype in women with recurrent miscarriage. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2015; (1): 25-31. (in Russian)]
- Кречетова Л.В., Степанова Е.О., Николаева М.А., Вторушина В.В., Голубева Е.Л., Хачатрян Н.А., Тетруашвили Н.К., Сухих Г.Т. Динамика субпопуляционного состава лимфоцитов периферической крови женщин с привычным выкидышем при предгестационной иммуноцитотерапии. Акушерство и гинекология. 2015; 4: 37-43. [Krechetova L.V., Stepanova E.O., Nikolaeva M.A., Vtorushina V.V., Golubeva E.L., Khachatryan N.A., Tetruashvili N.K., Sukhikh G.T. Time course of changes in the peripheral blood lymphocyte subpopulation composition of women with recurrent miscarriage during pregravid immunocytotherapy. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2015; (4): 37-43. (in Russian)]
- Кречетова Л.В., Тетруашвили Н.К., Вторушина В.В., Степанова Е.О., Николаева М.А., Голубева Е.Л., Хачатрян Н.А. Динамика субпопуляционного состава лимфоцитов периферической крови в первом триместре беременности у женщин с привычным выкидышем на фоне проведения иммуноцитотерапии. Акушерство и гинекология. 2015; 6: 59-66. [Krechetova L.V., Tetruashvili N.K., Vtorushina V.V., Stepanova E.O., Nikolaeva M.A., Golubeva E.L., Khachatryan N.A. Time course of changes in the subpopulation composition of peripheral blood lymphocytes in the first trimester of pregnancy in women with recurrent miscarriage during immunocytotherapy. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2015; (6): 59-66. (in Russian)]
- Sharma S. Natural killer cells and regulatory T cells in early pregnancy loss. Int. J. Dev. Biol. 2014; 58(2-4): 219-29.
- Somerset D.A., Zheng Y., Kilby M.D., Sansom D.M., Drayson M.T. Normal human pregnancy is associated with an elevation in the immune suppressive CD25+CD4+ regulatory T-cell subset. Immunology. 2004; 112: 38-43.
- Santillán I., Lozano I., Illán J., Verdú V., Coca S., Bajo-Arenas J.M., Martinez F. Where and when should natural killer cells be tested in women with repeated implantation failure? J. Reprod. Immunol. 2015; 108: 142-8.
- Zhao J.X., Zeng Y.Y., Liu Y. Fetal alloantigen is responsible for the expansion of the CD4(+)CD25(+) regulatory T cell pool during pregnancy. J. Reprod. Immunol. 2007; 75(2): 71-81.
- Xiong H., Zhou C., Qi G. Proportional changes of CD4+CD25+Foxp3+ regulatory T cells in maternal peripheral blood during pregnancy and labor at term and preterm. Clin. Invest. Med. 2010; 33(6): E422.
- Bogdan A., Polgar B., Szekeres-Bartho J. Progesterone induced blocking factor isoforms in normal and failed murine pregnancies. Am. J. Reprod. Immunol. 2014; 71(2): 131-6.
- Druckmann R., Druckmann M.A. Progesterone and the immunology of pregnancy. J. Steroid Biochem. Mol. Biol. 2005; 97(5): 389-96.
- Check J.H., Szekeres-Bartho J., O’Shaughnessy A. Progesterone induced blocking factor seen in pregnancy lymphocytes soon after implantation. Am. J. Reprod. Immunol. 1996; 35(3): 277-80.
- Raghupathy R., Al-Mutawa E., Al-Azemi M., Makhseed M., Azizieh F., Szekeres-Bartho J. Progesterone-induced blocking factor (PIBF) modulates cytokine production by lymphocytes from women with recurrent miscarriage or preterm delivery. J. Reprod. Immunol. 2009; 80(1-2): 91-9.
- Kelemen K., Bognar I., Paal M., Szekeres-Bartho J. A progesterone-induced protein increases the synthesis of asymmetric antibodies. Cell. Immunol. 1996; 167(1): 129-34.
- Arck P., Hansen P.J., Mulac Jericevic B., Piccinni M.P., Szekeres-Bartho J. Progesterone during pregnancy: endocrine-immune cross talk in mammalian species and the role of stress. Am. J. Reprod. Immunol. 2007; 58(3): 268-79.
- Szekeres-Bartho J., Weill B.J., Mike G., Houssin D., Chaouat G. Progesterone receptors in lymphocytes of liver-transplanted and transfused patients. Immunol. Lett. 1989; 22(4): 259-61.