Pregravid preparation in patients with the thin endometrium in assisted reproductive technology programs
- Authors: Serebrennikova K.G.1,2, Kuznetsova E.P.3, Vanke E.S.2, Ivanova T.V.2, Miloslavsky Y.V.2
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Affiliations:
- I.M. Sechenov 1st Moscow State Medical University
- Central Clinical Hospital of the Russian Academy of Sciences
- The first republican clinical hospital, Ministry of Health of the Udmurt Republic
- Issue: No 3 (2017)
- Pages: 139-146
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247997
- DOI: https://doi.org/10.18565/aig.2017.3.139-46
- ID: 247997
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Abstract
Objective. To evaluate the efficiency of pregravid preparation using a specialized complex and hormonal therapy in patients with diagnosed infertility and clinical presentations of the thin endometrium. Subjects and methods. The investigation enrolled 145patients aged 25-42 years with an established diagnosis of infertility and a history of superovulation using GnRH agonists and antagonists. Group 1 included 65 patients who had undergone a surgery on the ovaries and received no pregravid preparation; Group 2 consisted of 60patients who had a surgery on the ovaries and pregravid preparation for assisted reproductive technology (ART) programs during 2-3 months as the complex Pregnoton in combination with hormone therapy. The comparison group comprised 20 patients with intact ovaries and tuboperitoneal factor infertility. The investigation was conducted within the preparation of patients for an assisted reproductive technology protocol. Results. After implementing the ART protocol, pregnancy occurred in 15.5, 31.7, and 35% of cases in Groups 1, 2, and 3, respectively. Conclusion. Comprehensive pregravid preparation, including the complex Pregnoton in combination with hormonal therapy, makes it possible not only to increase the rate of pregnancy, but also to lower a risk for pregnancy complications, and thus affecting perinatal and infant losses.
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About the authors
Klara Georgievna Serebrennikova
I.M. Sechenov 1st Moscow State Medical University; Central Clinical Hospital of the Russian Academy of Sciences
Email: klaraserebrennikova@mail.ru
MD, professor; Scientific adviser on obstetrics and gynecology
Elena Petrovna Kuznetsova
The first republican clinical hospital, Ministry of Health of the Udmurt Republic
Email: doctorfamily@mail.ru
MD, associate professor, chief freelance specialist of the Ministry of Health of the Udmurt Republic for reproduction, head of the ECO Center and reproductions
Ekaterina Sergeevna Vanke
Central Clinical Hospital of the Russian Academy of Sciences
Email: vanke_katy@mail.ru
obstetrician-gynecologist of the gynecological department
Tatyana Vitalievna Ivanova
Central Clinical Hospital of the Russian Academy of Sciences
Email: embryodoc@mail.ru
embryologist of the department of the ART
Yuri Viktorovich Miloslavsky
Central Clinical Hospital of the Russian Academy of Sciences
Email: md_miloslavsky@mail.ru
obstetrician-gynecologist of the gynecological department
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