Endometrial glycome in the menstrual cycle and endometrial receptivity


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Abstract

Objective. To carry out a systematic analysis of the data available in the current literature on the cyclicity of endometrial glycomic changes and their impact on receptivity and implantation. Material and methods. The review includes the data of 46 foreign and Russian articles published in the past 22 years and found in the Pubmed database on this topic. Results. Endometrial glycomic changes are described in relation to the phase of the menstrual cycle. The maximum glycomic changes are shown to be observed during the implantation window. The changes in the expression of endometrial epithelium glycans are demonstrated to regulate both positively and negatively implantation. Conclusion. The endometrial glycomic differences established in the proliferative and secretory phases of the cycle suggest that glycans are involved in implantation as determinants of receptivity. The data presented may contribute to increasing knowledge on the pathogenesis of infertility and indicate the need for further investigations aimed at identifying glycans as markers for endometrial receptivity in order to enhance the effectiveness of assisted reproductive technology programs.

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About the authors

Marina Mikhailovna Ziganshina

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: mmz@mail.ru
Ph.D., Senior Researcher, Laboratory of Clinical Immunology

Nigora Farukhovna Abdurakhmanova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: abd.nigora@yandex.ru
post-graduate student of the 1st year of the Department of Auxiliary Technologies in Infertility Treatment

Stanislav Vladislavovich Pavlovich

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University

Email: st.pavlovich@mail.ru
Ph.D., Associate Professor, Scientific Secretary; Professor of the Department of Obstetrics, Gynecology, Perinatology, and Reproductology, Institute of Professional Education

Anna Dmitrievna Gvozdeva

M.V. Lomonosov Moscow State University

Email: gvozdevaannalech@gmail.com
5th-year student of the Faculty of Fundamental Medicine

Nikolai Vladimirovich Bovin

Academicians M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Email: professorbovin@yandex.ru
Doctor of Chemical Sciences, Professor, Head of the Department of Laboratory of Carbohydrate Chemistry

Gennady Tikhonovich Sukhikh

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Email: gtsukhikh@mail.ru
Academician of the Russian Academy of Sciences, MD, Professor, Honored Scientist of the Russian Federation, Director; Professor of the Department of Obstetrics, Gynecology, Perinatology, and Reproductology, Institute of Professional Education

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