Prediction of outcomes in assisted reproductive technology programs by determining telomere length and telomerase activity in cumulus cells and lymphocytes


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Abstract

Objective. To carry out a systematic analysis of scientific data on the efficiency of determining telomere length and telomerase activity in follicular cumulus cells and peripheral blood lymphocytes, as well as a correlation of this indicator with the outcomes of in vitro fertilization programs. Material and methods. The review includes the data of foreign and Russian articles published in the past 7 years and found in Pubmed on this topic. Results. Based on the analyzed literature data, the authors have concluded that the study of telomere length and telomerase activity in the follicular cumulus cells and peripheral blood lymphocytes is a relevant and promising method for predicting the outcomes of assisted reproductive technology programs. Conclusion. There is a need for further investigations assessing the correlation of telomere length and telomerase activity in the follicular cumulus cells and peripheral blood lymphocytes with the quality of oocytes and embryos, as well as with the effectiveness of infertility treatment programs involving in vitro fertilization techniques.

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About the authors

Elizaveta Evgenievna Kraevaya

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kraevaya@oparina4.ru
junior researcher of department of assisted reproductive technology in treating sterility

Denis Sergeevich Nalobin

M.V. Lomonosov Moscow State University

Email: Nalobin@mail.bio.msu.ru
PhD, senior researcher of the Biological Faculty

Alexandr Ivanovich Glukhov

M.V. Lomonosov Moscow State University

Email: glukhov.ai@1msmu.ru
Sc.D., Professor, Leading Researcher of the Biological Faculty

Natalia Petrovna Makarova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: np_makarova@oparina4.ru
PhD, Senior Researcher of department of assisted reproductive technology in treating sterility

Elena Anatolievna Kalinina

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kalinina@oparina4.ru
MD, Associate Professor, The chief of department of assisted reproductive technology in treating sterility

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