Role of HOX genes associated with infertility in female reproductive system diseases


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Abstract

Objective. To carry out a systematic analysis of the data available in the current literature on the role of HOX genes in realizing the reproductive potential in women. Material and methods. The review includes the data of foreign and Russian articles published in the past 10 years and found in Pubmed on this topic. The search depth was 7years. Results. The paper gives data on the impaired work of individual genes of the HOX gene family in a number of reproductive system diseases: endometriosis, uterine fibroids, chronic endometritis, etc. It highlights that the НОХА10 and НОХА11 genes are important in the regulation of endometrial receptivity and describes that there may be a relationship between these genes and infertility. Conclusion. The results of the performed investigations conf irm the prospect and urgency of a study of the role of the НОХА10 and НОХА11 genes in the etiology of infertility, as well as methods for influencing the expression of the above genes.

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About the authors

Ekaterina Andreevna Knyazeva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: dr.knyazeva.ea@gmail.com
post-graduate student of the Department of Auxiliary Technologies in Infertility Treatment

Elena Anatolievna Kalinina

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_kalinina@oparina4.ru
MD, associate professor, head of the department of assistive technologies in infertility treatment

Andrey A. Bystritsky

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: andrey.bystritskiy@yandex.ru
Cand. Sc. (Biology), Leading Researcher of the Laboratory of Molecular Genetic Methods

Kamila Ullubievna Alieva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kaya79@mail.ru
Ph.D., doctor of the department of auxiliary technologies in infertility treatment

Gyuldana Raufovna Bairamova

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: bayramova@mail.ru
MD, head of the department, on the clinical work of the scientific and polyclinic department

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