Clinical significance of predictors for preeclampsia: prediction capabilities


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Abstract

Objective. To identify preeclampsia predictors in the general population of pregnant women. Subjects and methods. The investigation enrolled 92 patients who had been followed up in Saint Petersburg Women’s Health Clinic Twenty-Two in 2014-2015. They were examined for the carriage of genetic markers for thrombophilia and that of the genes involved in the regulation of endothelial function and for the serum level of placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1). Results. Assessment of delivery outcomes revealed no symptoms of preeclampsia in 74 pregnant women observed during the first and the second trimester. 18 pregnant women showed signs of varying severities of preeclampsia. According to the findings, the elevated sFlt-1/PlGF ratio of above 34.0 in the first trimester of pregnancy and 37.5 in the second trimester was taken in our laboratory as reference values for the preliminary prediction of preeclampsia. The ratio of sFlt-1/PlGF higher than the average level was observed in pregnant women with the most severe forms of preeclampsia. Conclusion. The elevated serum sFIt-1/PlGF ratio is an early markerfor preeclampsia and suggests that the latter may develop. The value of this indicator is associated with the severity of preeclampsia.

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About the authors

A. E Nikolaeva

Women's Health Clinic Twenty-Two; Saint Petersburg State Pediatric Medical University

Email: alla-nikolaeva2007@yandex.ru
MD, PhD, Research assistant at Department of Gynecology and Women’s Reproductology with Pediatric Gynecology Course; Deputy chief physician for medicine

I. A Kaika

Women's Health Clinic Twenty-Two

Email: irina2668@mail.ru
MD, hematologist

E. Yu Yuabova

Women's Health Clinic Twenty-Two

Email: kdl22@yandex.ru
MD, PhD, Chief of the clinical diagnostic laboratory

F. R Kutueva

Women's Health Clinic Twenty-Two

Email: flora-kutueva@mail.ru
Chief

G. F Kutusheva

Saint Petersburg State Pediatric Medical University

Email: galia.kutusheva@yandex.ru
Chief of Department of Gynecology and women’s reproductology with Pediatric Gynecology Course

S. I Kapustin

Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russia

Email: kapustin.sergey@mail.ru
Doctor of Biological Sciencies, Phd, Chief of the laboratory of biochemistry

T. L Kachanova

V.I. Ulyanov (Lenin) Saint Petersburg State Electrotechnical University «LETI»

Email: kachanova-tamara@mail.ru
PhD, Doctor of Technical Sciencies, Professor of Department of Automatics and Operational Processes

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