Effects of anthropogenic chemicals on reproduction


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Abstract

Objective. To carry out a systematic analysis of the data available in the current literature on the effects of some anthropogenic chemicals on human fertility, including on the effectiveness of assisted reproductive technology programs. Material and methods. The review includes the articles by foreign and Russian authors on this topic, which have been published in the Pubmed journals in the past 10 years. Results. The authors analyze the literature data on the effects of heavy metals, phthalates, and bisphenol A on various aspects of human reproductive function. They present data on the possible pathogenetic mechanisms of action of anthropogenic chemicals on the quality of gametes and the efficiency of treatment for infertility. Conclusion. It is necessary to further study the molecular mechanisms of negative action of toxicants on human fertility in order to determine management tactics in infertility patients.

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About the authors

Anastasia Grigorievna Syrkasheva

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_syrkasheva@oparina4.ru
M.D., Ph.D., Researcher of the IVF Department

Nataliya Vitalievna Dolgushina

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_dolgushina@oparina4.ru
M.D., Ph.D., M.P.H., Head of R&D Department

Ekaterina Lvovna Yarotskaya

Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_yarotskaya@oparina4.ru
M.D., Ph.D., Head of the Department for International Cooperation

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