Very early premature birth and isthmic-cervical insufficiency in pregnancy resulting from assisted reproductive technologies
- Authors: Malgina G.B.1, Fassakhova A.F.1, Tretyakova T.B.1, Brusnitsyna V.J.1, Rykosuev N.Y.1
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Affiliations:
- Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia
- Issue: No 5 (2018)
- Pages: 44-49
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248176
- DOI: https://doi.org/10.18565/aig.2018.5.44-49
- ID: 248176
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Abstract
Objective. To identify risk factors for very early premature birth (VEPB) and isthmic-cervical insufficiency (ICI) in pregnancy resulting from assisted reproductive technologies (ART). Subjects and methods. Step 1 was to retrospectively assess perinatal outcomes in 483 pregnant women after ART and in 645patients with natural conception. Step 2 was to conduct a case-control study. A study group included 76 pregnant women after ART with ICI: 33 and 43 women had singleton and multiple pregnancies, respectively. A control group consisted of 67 pregnant women after ART with no ICI: 37 and 30 women with singleton and multiple pregnancies, respectively. Results. Odds ratio (OR) for ICI after ART was 5.5 with 95% CI, 3.6-8.4; p < 0.05. OR for VEPB after ART was 3.3 with 95% CI, 1.4 to 8.1; p< 0.05. ICI in VEPB was detected in 75.6%. The risk factors for ICI after ART are 3 or more attempts of the latter, the lack of long-term hormonal support and cervicometry. In singleton pregnancy, the additional risk factors are a history of early miscarriages, as well as endocrinopathy. Conclusion. Cervicometry and prolonged progestin support are recommended for the prevention of ICI during pregnancy after ART.
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About the authors
Galina B. Malgina
Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia
Email: galinamalgina@mail.ru
Professor, Head of Science
Aigul F. Fassakhova
Ural Research Institute of Maternal and Infant Care, Ministry of Health of RussiaJunior Researcher, Scientific Department of Antenatal Fetal Care
Tatyana B. Tretyakova
Ural Research Institute of Maternal and Infant Care, Ministry of Health of RussiaPhD, Senior Researcher, Scientific Department of Biochemistry with Genetics Group
Vera. Ju. Brusnitsyna
Ural Research Institute of Maternal and Infant Care, Ministry of Health of Russia
Email: verabru@mail.ru
Senior Researcher, Scientific Department of the Preservation of Reproductive Function
Nikita Ye. Rykosuev
Ural Research Institute of Maternal and Infant Care, Ministry of Health of RussiaJunior Researcher, Scientific Department of Biochemistry with Genetics Group
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