EVALUATION OF THE CARDIOVASCULAR SAFETY OF MENOPAUSAL HORMONE THERAPY IN EARLY POSTMENOPAUSAL WOMEN


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Abstract

Objective. To evaluate the cardiovascular safety of long-term use of a combination of 1 mg 17β-estradiol and 2 mg drospirenone (DRSP) (1 mg E2/2 mg DRSP) in early postmenopausal women. Subjects and methods. A total of 162 early postmenopausal women were examined and divided into 2 groups: 1) 84 patients who were on menopausal hormone therapy (MHT) with 1 mg E2/2 mg DRSP (Angeliq) (a study group); 2) 78 women who did not receive MHT (a control group). The follow-up period was 5.2 years. The severity of abdominal obesity and oral glucose tolerance test and hemostatic parameters were estimated. Results. Long-term MHT is associated with a significant decrease in waist circumference (WC) and waist-hip ratio (WHR) throughout the follow-up period. The control group showed a significant increase in WC and WHR. Long-term MHT is associated with a decrease in the probability of developing carbohydrate metabolic disturbances (OR, 0.42; 95% CI, 0.17-1.04) and in the incidence of hypertension (OR, 0.69; 95% CI, 0.34-1.38). The circadian blood prof ile was normalized in women on MHT. The changes in endothelium functional activity (von Willebrand factor antigen, antithrombogenic activity of the vascular wall) suggest that long-term MHT with 1 mg E2/2 mg /DRSP had no negative impact on the endothelium. Conclusion. The combination of 1 mg E2/2 mg DRSP used in the long-term MHT in early postmenopausal women demonstrated its efficacy, safety, and additional positive effects.

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About the authors

Igor A. SALOV

Email: salovia@mail.ru
MD, PhD, Head of Department of Obstetrics and Gynecology, V.I. Razumovsky Saratov State Medical University, Ministry of Health of Russia. 410012, Russia, Saratov, B. Kazachya str. 112

Sergey N. TOLSTOV

Email: tolstovsn@mail.ru
MD, PhD, assistant of the Department of Therapy, V.I. Razumovsky Saratov State Medical University, Ministry of Health of Russia. 410012, Russia, Saratov, B. Kazachya str. 112

Andrey P. REBROV

Email: andreyrebrov@yandex.ru
MD, PhD, Head of Department of Therapy, V.I. Razumovsky Saratov State Medical University, Ministry of Health of Russia. 410012, Russia, Saratov, B. Kazachya str. 112

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