The possibility of neoplastic transformation of ovarian endometriosis


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Abstract

Objective. To investigate the signs of neoplastic transformation of the epithelium in the foci of ovarian endometriosis (OE). Material and methods. Histological and immunohistochemical examinations were used to study 78 and 35 OE cases, respectively, and 8 adenocarcinomas. Anti-Ki-67, anti-Bcl-2, anti-p53, and anti-hepatocyte nuclear factor-1ß (HNF-1ß) antibodies were employed. Results. The epithelium of endometrioid cyst walls showed papillary syncytial changes (39.7%), metaplasia with clear cytoplasm cells (15.4%), and epithelial atypia with a low-to-relatively low Ki-67 and Bcl-2 expression and with a low p53 expression (41.0%). The expression of HNF-1ß in the foci with and without atypia was revealed in 94.7 and 56.3% of cases, respectively; it was detected only in clear cell adenocarcinomas. Conclusion. HNF-1ß hyperexpression suggests the adaptive nature and histogenetic relationship of OE to clear cell tumors of the ovary.

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About the authors

Tatyana Aleksandrovna Gromova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Email: tgromova928@yandex.ru
post-graduate student of the Department of Obstetrics and Gynecology of the Faculty of Medicine

Natalia Alekseevna Sheshukova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Email: dr.sheshukova@mail.ru
MD, Professor of the Department of Obstetrics and Gynecology of the Faculty of Physiology

Olesya Viktorovna Bolshakova

Bakhrushins Brothers City Clinical Hospital, Moscow Healthcare Department

Candidate of Medical Sciences, Head of the gynecological department

Oleg Vadimovich Zairatyants

A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia

Email: ovzair@mail.ru
MD, professor, head of the Department of Pathological Anatomy

Sergey Alexandrovich Levakov

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia

Email: levakoff@yandex.ru
MD, Professor, Head of the Department of Obstetrics and Gynecology of the Medical Faculty

Evgeniy Viktorovich Fedotov

A.K. Eramishantsev City Clinical Hospital, Moscow Healthcare Department

Candidate of Medical Science, Head of the pathoanatomical department

References

  1. Jiang Q.Y., Wu R.J. Growth mechanisms of endometriotic cells in implanted places: a review. Gynecol. Endocrinol. 2012; 28(7): 562-7. doi: 10.3109/09513590.2011.650662.
  2. Леваков С.А., Громова Т.А., Кедрова А.Г., Шешукова Н.А. Эндометриозассоциированный рак яичников. Опухоли женской репродуктивной системы. 2016; 12(4): 47-51.
  3. Pearce C.L., Templeman C., Rossing M.A., Lee A., Near A.M., Webb P.M. et al. Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies. Lancet 0ncol. 2012; 13(4): 385-94. doi: 10.1016/S1470-2045(11)70404-1.
  4. Krawczyk N., Banys-Paluchowski M., Schmidt D., Ulrich U., Fehm T. Endometriosis-associated malignancy. Geburtshilfe Frauenheilkd. 2016; 76(2): 176-81. doi: 10.1055/s-0035-1558239.
  5. Yu H.C., Lin C.Y., Chang W.C., Shen B.J., Chang WP, Chuang C.M. et al. Increased association between endometriosis and endometrial cancer: a nationwide population-based retrospective cohort study. Int. J. Gynecol. Cancer. 2015; 25(3): 447-52. doi: 10.1097/IGC.0000000000000384.
  6. Amano Y., Mandai M., Yamaguchi K., Matsumura N., Kharma B., Baba T. et al. Metabolic alterations caused by HNF1ß expression in ovarian clear cell carcinoma contribute to cell survival. Oncotarget. 2015; 6(28): 26002-17. doi: 10.18632/oncotarget.4692.
  7. Mandai M., Amano Y., Yamaguchi K., Matsumura N., Baba T., Konishi I. Ovarian clear cell carcinoma meets metabolism; HNF-1ß confers survival benefits through the Warburg effect and ROS reduction. Oncotarget. 2015; 6(31): 30704 14. doi: 10.18632/oncotarget.5228
  8. Suzuki E., Kajita S., Takahashi H., Matsumoto T., Tsuruta T., Saegusa M. Transcriptional upregulation of HNF-1ß by NF-kB in ovarian clear cell carcinoma modulates susceptibility to apoptosis through alteration in bcl-2 expression. Lab. Invest. 2015; 95(8): 962-72. doi: 10.1038/ labinvest.2015.73.
  9. DeLair D., Han G., Irving J.A., Leung S., Ewanowich C.A., Longacre T.A. et al. HNF-1ß in ovarian carcinomas with serous and clear cell change. Int. J. Gynecol. Pathol. 2013; 32(6): 541-6. doi: 10.1097/PGP.0b013e318273fd07.
  10. Hoang L.N., Han G., McConechy M., Lau S., Chow C., Gilks C.B. et al. Immunohistochemical characterization of prototypical endometrial clear cell carcinoma-diagnostic utility of HNF-1ß and oestrogen receptor. Histopathology. 2014; 64(4): 585-96. doi: 10.1111/his.12286.
  11. Kao Y.C., Lin M.C., Lin W.C., Jeng Y.M., Mao T.L. Utility of hepatocyte nuclear factor-1ß as a diagnostic marker in ovarian carcinomas with clear cells. Histopathology. 2012; 61(5): 760-8. doi: 10.1111/ j.1365-2559.2012.04267.x.
  12. Kurman R.J., Ellenson H., Ronnett L., Brigitte M., eds. Blaustein’s pathology of the female genital tract. 6th ed. Springer; 2011.
  13. Kurman R.J., Carcanglu M.L., Herrington C.S., Young R.H., eds. WHO classification of tumours of female reproductive organs. 4th ed. Lyon: WHO Press; 2014.
  14. Zaino R., Carinelli S.G., Ellenson L.H. Tumours of the uterine corpus: epithelial tumours and precursors. Lyon: WHOPress; 2014: 125-6.
  15. Brinkmann V., Abu Abed U., Goosmann C., Zychlinsky A. Immunodetection of NETs in paraffin-embedded tissue. Front. Immunol. 2016; 7: 513. eCollection 2016.
  16. Mojiri A., Stoletov K., Carrillo M.A., Willetts L., Jain S., Godbout R. et al. Functional assessment of von Willebrand factor expression by cancer cells of non-endothelial origin. Oncotarget. 2017; 8(8): 13015-29. doi: 10.18632/ oncotarget.14273.
  17. Cohen D.A., Dabbs D.J., Cooper K.L., Amin M., Jones T.E., Jones M.W. et al. Interobserver agreement among pathologists for semiquantitative hormone receptor scoring in breast carcinoma. Am. J. Clin. Pathol. 2012; 138(6): 796-802. doi: 10.1309/AJCP6DKRND5CKVDD.
  18. Клинические рекомендации «Эндометриоз: диагностика, лечение и реабилитация». М.; 2013.
  19. Зайратьянц О.В., Адамян Л.В., Андреева Е.Н., Максимова Ю.В., Мурдалова З.Х., Опаленов К.В., Мовтаева Х.Р., Сонова М.М., Зарубина И.П. Молекулярно-биологические особенности эктопического и эутопического эндометрия при генитальном эндометриозе. Архив патологии. 2010; 72(5): 6-12.

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