Early predictors of preeclampsia
- Authors: Dubrovina S.O.1, Mutsalkhanova U.S.1, Vasilyeva V.V.1
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Affiliations:
- Rostov State Medical University
- Issue: No 10 (2018)
- Pages: 47-51
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248262
- DOI: https://doi.org/10.18565/aig.2018.10.47-51
- ID: 248262
Cite item
Open Access
Access granted
Abstract
Objective. To investigate the clinical, anamnestic, and biochemical predictors of preeclampsia. Subjects and methods. Clinical, anamnestic, and biochemical examinations were performed in pregnant women, who later formed two groups: pregnant women with late-onset moderate preeclampsia and patients without preeclampsia. Results. The significant clinical markers for late-onset preeclampsia were shown to be increases in body mass index and mean blood pressure at 11-13 weeks’ gestation. The pregnant women with preeclampsia were found to have significantly higher serum levels of retinol-binding protein 4 and disintegrin and metalloproteinase 12. The anamnestic predictors of preeclampsia were ascertained to be hypertension in the history, chronic pyelonephritis, and preeclampsia in previous pregnancies. Conclusion. A prognostic model based on the co-use of the studied predictors has been developed for the early prediction of late-onset moderate preeclampsia.
Keywords
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About the authors
Svetlana Olegovna Dubrovina
Rostov State Medical University
Email: s.dubrovina@gmail.com
MD, PhD, Professor, the main scientific researcher
Ulduz Sultanovna Mutsalkhanova
Rostov State Medical University
Email: yulduzka111@mail.ru
postgraduate student
Valentina Valer'evna Vasilyeva
Rostov State Medical University
Email: v.vasiljeva1965@mail.ru
PhD, assoc. prof., leading researcher
References
- Duhig K.E., Shennan A.H. Recent advances in the diagnosis and management of pre-eclampsia. F1000 Prime Reports. 2015; 7: 24.
- Gallo D., Poon L.C., Fernandez M., Wright D., Nicolaides K.H. Prediction of preeclampsia by mean arterial pressure at 11-13 and 20-24 weeks’ gestation. Fetal Diagn. Ther. 2014; 36(1): 28-37.
- Сухих Г.Т., Ванько Л.В. Иммунные факторы в этиологии и патогенезе осложнений беременности. Акушерство и гинекология. 2012; 1: 128-36.
- Фомина М.П. 3D-допплерометрия плацентарного кровотока в прогнозировании синдрома задержки роста плода. Журнал акушерства и женских болезней. 2013; 62(2): 160-5.
- Zenclussen A.C. Adaptive immune responses during pregnancy. Am. J. Reprod. Immunol. 2013; 69(4): 291-303.
- Bakker R., Steegers E.A., Hofman A., Jaddoe V. Blood pressure in different gestational trimesters, fetal growth, and the risk of adverse birth outcomes: the generation R. study. Am. J. Epidemiol. 2011; 174(7): 797-806.
- Bateman B.T., Bansil P., Hernandez-Diaz S., Mhyre J.M., Callaghan W.M., Kuklina E.V. Prevalence, trends, and outcomes of chronic hypertension: a nationwide sample of delivery admissions. Am. J. Obstet. Gynecol. 2012; 206(2): 134-8.
- Baschat A.A., Magder L.S., Doyle L.E., Atlas R.O., Jenkins C.B., Bilizer M.G. Prediction of preeclampsia utilizing the first trimester screening examination. Am. J. Obstet. Gynecol. 2014; 211(5): 514. e1-7.
- Sung K., Roh A.J., Eoh K., Kim E. Maternal serum placental growth factor and pregnancy-associated plasma protein A measured in the first trimester as parameters of subsequent preeclampsia and small-for-gestational-age infants: A prospective observational study. Obstet. Gynecol. Sci. 2017; 60(2): 154-62.
- Giguere Y., Masse J., Theriault S., Bujold E., Laford J., Rosseau F. et al. Screening for preeclampsia early in pregnancy: performance of a multivariable model combining clinical characteristics and biochemical markers. BJOG. 2015; 122(3): 402-10.
- O’Gorman N., Wright D., Poon L., Rolnik D., Syngelaki A., de Alvarado M. et al. Multicenters creening for preeclampsia by maternal factors and biomarkers at 11-13 weeks’ gestation: comparison to NICE guidelines and ACOG recommendations. Ultrasound Obstet. Gynecol. 2017; 49(6): 756-60.
- Myatt L., Clifton R.G., Roberts J.M., Spong C.Y., Hauth J.C., Varner M.W. et al.; Eunice Kennedy Shriver National Institute of Child Health and Human Development [NICHD] Maternal-Fetal Medicine Units [MFMU] Network. First-trimester prediction of preeclampsia in nulliparous women at low risk. Obstet. Gynecol. 2012; 119(6): 1234-42.
- Matwejew E., Cowans N.J., Stamatopoulou A., Spencer K., von Kaisenberg C.S. Maternal serum ADAM-12 as a potential marker for different adverse pregnancy outcomes. Fetal Diagn. Ther. 2010; 27(1): 32-9.
- Wright D., Syngelaki A., Akolekar R., Poon L.C., Nicolaides K.H. Competing risks model in screening for preeclampsia by maternal characteristics and medical history. Am. J. Obstet. Gynecol. 2015; 213(1): 1-10.
- Zhang J.Z., He J. Risk factors of recurrent preeclampsia and its relation to maternal and offspring outcome. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2015; 44(3): 258-63.
- Itoh H., Kanayama N. Obesity and risk of preeclampsia. Med. J. Obstet. Gynecol. 2014; 2(2): 1024.
- Iacobelli S., Bonsante F., Robillard P.Y. Comparison of risk factors and perinatal outcomes in early onset and late onset preeclampsia: A cohort based study in Reunion Island. J. Reprod. Immunol. 2017; 123: 12-6.
- Воднева Д.Н., Шмаков Р.Г., Щеголев А.И. Роль маркеров инвазии трофобласта в развитии преэклампсии и опухолевой прогрессии. Акушерство и гинекология. 2013; 11: 9-12.
- Metcalfe A., Langlois S., Macfarlane J., Vallance H., Joseph K.S. Prediction of obstetrical risk using maternal serum markers and clinical risk factors. Prenat. Diagn. 2013; 34(2): 172-9.
- Mendola P., Ghassabian A., Mills J.L., Zhang C., Tsai M.Y., Liu A., Yeung E.H. Retinol-binding protein 4 and lipids prospectively measured during early to mid-pregnancy in relation to preeclampsia and preterm birth risk. Am. J. Hypertens. 2017; 30(6): 569-76.
- Al-Kholy A., Abadier M., Rageh E., El-Kallaf H. Serum levels of placental growth factor and retinol-binding protein-4 in pregnancy-induced hypertensive women. J. Am. Sci. 2010; 6(12): 448-55.
- Bredaki F.E., Mataliotakis M., Wright A., Wright D., Nicolaidse K.H. Maternal serum alpha-fetoprotein at 12, 22 and 32 weeks’ gestation in screening for preeclampsia. Ultrasound Obstet. Gynecol. 2016; 47(4): 466-71.
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