Comprehensive assessment of the postoperative period after uterine artery embolization based on stress response markers and Doppler imaging of uterine blood flow reduction
- Authors: Syutkina I.P.1, Khabarov D.V.1, Rakitin F.A.1, Shchedrova V.V.1
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Affiliations:
- Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
- Issue: No 10 (2018)
- Pages: 64-70
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248286
- DOI: https://doi.org/10.18565/aig.2018.10.64-70
- ID: 248286
Cite item
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Abstract
Aim. To assess the postoperative period after uterine artery embolization (UAE) based on the changes in clinical and immune-biochemical indicators of the stress response and Doppler imaging of uterine blood flow reduction. To investigate the relationship between the intensity of the immune-biochemical response, pain syndrome severity, and ultrasound-detected arterial blood flow reduction in fibroids. Materials and methods. In this pilot study, 60 patients undergoing UAE were tested for the immunobiochemical stress response profile, evaluated for the intensity of pain using a visual analog scale, and the degree of uterine blood flow reduction based on Doppler color flow mapping. Doppler color flow mapping was used to observe peripheral and internal fibroid arteries and uterine arteries. Results. UAE resulted in a marked decrease in the uterine and fibroid arterial perfusion, followed by an increase in serum levels of IL-1, IL-6, TNFα, IL-4, IL-10, CRP, ACTH, cortisol, and glucose. In these cases, 100% of patients developed postoperative pain syndrome. Conclusion. The intensity of the stress response depends on the extent of the fibroid blood flow reduction and uterine arterial perfusion after UAE. Changes in the immuno-biochemical profile develop in parallel with the intensity of pain syndrome and ultrasound signs of aseptic necrosis of fibroids and perifocal inflammation in the uterine wall.
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About the authors
Irina P. Syutkina
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: lymphology@niikel.ru; komarok777@mail.ru
Junior Researcher, Laboratory for Operative Surgery and Lymphodetoxication, Anesthesiologist and Intensivist
Dmitrii V. Khabarov
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: hdv@ngs.ru
Dr.Med.Sci., Leading Researcher of the Laboratory of Operational Surgery and Lymphodetoxication, Head of the Department of Anaesthesiology and Intensive Care
Fedor A. Rakitin
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: rakitinfedorr@mail.ru
Head of the Department of Gynecology
Valentina V. Shchedrova
Research Institute of Clinical and Experimental Lymphology, Affiliated Branch of Federal Research Center of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences
Email: sheval79@mail.ru
Gynecologist, Diagnostic Medical Sonographer
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