Implication of vitamin D deficiency in the development of severe forms of preeclampsia in women at high risk


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Abstract

Objective. To investigate vitamin D provision in women at high risk for preeclampsia and to reduce the occurrence of its severe form by correcting vitamin D deficiency during pregnancy and pregravid preparation. Subjects and methods. The investigation enrolled 172 patients at high risk for preeclampsia; among them, there were 102 patients who took vitamin D and calcium and 70patients who did not. Over the course of gestation, the serum concentrations of vitamin D, vitamin D-binding protein, ionized calcium, renin, and endothelin 1-38 were measured in the women, and the umbilical cord blood levels of 25(OH)D were estimated in their newborns. Results. The women at risk for preeclampsia have vitamin D deficiency. The use of Aquadetrim 4000IU and Ca 500 mg as from the stage of pregravid preparation prevents preeclampsia and severe perinatal injuries. Conclusion. Increasing the dose of vitamin D up to 4000 IU from the stage of pregravid preparation and during pregnancy is optimal for women at high risk for preeclampsia.

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About the authors

Larisa I. Maltseva

Kazan State Medical Academy

Email: laramalc@mail.ru
MD, professor, head of the Obstetrics and Gynecology Department № 1

Elvira N. Vasilyeva

I.N. Ulyanov Chuvash State University

Email: elnikvas@mail.ru
PhD in Medical Sciences, associate professor of the department of Obstetrics and Gynecology

Tamara G. Denisova

I.N. Ulyanov Chuvash State University; Institute for Postgraduate Training of Physicians, Ministry of Health of Chuvashia

Email: tomadenisova@rambler.ru
MD, professor, Vice-Rector for Research and Informatization, Institute for Postgraduate Training of Physicians, Ministry of Health of Chuvashia; professor of the department of Obstetrics and Gynecology

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