Endometriosis, adenomyosis, chronic endometritis: clinical and pathogenetic relationships and reproductive failure


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Abstract

The article highlights the clinical and pathogenetic relationships between endometriosis/adenomyosis and chronic endometritis (CE) within reproductive failures. It describes a cause-and-effect relationship between endometriosis/ adenomyosis and CE by the example of its clinical symptomatology and the pathogenic mechanisms involving an autoimmune process, aseptic inflammation, and altered endometrial receptivity. Endometriosis/adenomyosis and CE have a number of common pathogenetic mechanisms of development and clinical manifestations (infertility, recurrent miscarriages, and assisted reproductive program failures). This implies the necessity to qualitatively assess the endometrium in women with endometriosis and adenomyosis during pregravid preparation, as well as the search for new therapeutic ways to correct autoimmune disorders. The use of sodium desoxyribonucleate (derinat) showing the pharmacological properties of an activator of the cellular and humoral immune system and a stimulator of reparative and regenerative processes is a promising approach to drug therapy.

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About the authors

Ara L. Unanyan

I.M. Sechenov First Moscow State Medical University

Email: 9603526@mail.ru
MD, Professor of the Department of Obstetrics and Gynecology № 1 of the Faculty of Medicine, Head of the Clinical Base of the Department of Obstetrics and Gynecology № 1 of the Faculty of Medicine

Iraida S. Sidorova

I.M. Sechenov First Moscow State Medical University

Email: sidorovais@yandex.ru
Academician of RAS, Honored Scientist of the Russian Federation, Honored Doctor of the Russian Federation, Professor, MD, Professor of the Department of Obstetrics and Gynecology № 1 of the Faculty of Medicine

Evgenia A. Kogan

I.M. Sechenov First Moscow State Medical University

MD, professor, full member of the Russian division of the International Academy of Pathology, Head of the Department

Sofiya Yu. Belogubova

I.M. Sechenov First Moscow State Medical University

Email: belogubovasofia@gmail.com
a 6th year student of the International School “Medicine of the Future” of the Faculty of Medicine

Tatyana A. Demura

I.M. Sechenov First Moscow State Medical University

MD, professor of the Department of Pathology

Aleksandra M. Elisavetskaya

Women's Consultation Clinic Seven, Branch, Maternity Hospital Twenty-Five, N.I. Pirogov City Clinical Hospital One, Moscow Healthcare Department

Email: gkbl@zdrav.mos.ru
head

Natalia M. Sizova

National Medical Research Center of Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov

Email: sizova-natasha@yandex.ru
obstetrics and gynecology resident doctor

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