Psychopathological features and endocrine and metabolic profile in patients with functional hypothalamic amenorrhea


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Abstract

Objective. To assess the mental status of patients with functional hypothalamic amenorrhea (FHA) and the relationship of the mental status to the endocrine and metabolic profile. Subjects and methods. A total of 104 women (mean age, 25,8 ± 4,2 years; body mass index (BMI), 20.1 ± 1.9 kg/m2) with FHA were examined. A psychiatric interview was performed; the plasma levels of hormones and neurotransmitters and the body’s composition were assessed. Results. Mental disorders were found in 94% of patients with FHA; 35% of them had eating disorders (EDs), there were anxiety disorders (25%), depression (D) (20%), and bipolar spectrum disorders (BSDs) (13%). Hypoleptinemia was detected in 80%. Patients with EDs or BSDs had higher cortisol levels; those with D had lower serotonin levels. The content of adipose tissue ranged from 11 to 37%. Its deficiency was present in 76% of patients with FHA, especially in those with EDs and BSDs. Conclusion. FHA is associated with mental disorders, EDs, energy imbalance, and hypoleptinemia. The suppressed hypothalamus-pituitary-ovarian axis in FHA is evidently a consequence of metabolic adaptation to energy deficiency.

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About the authors

Galina E. Chernukha

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia

Email: c-galina1@yandex.ru
MD, professor

Alexey E. Bobrov

Moscow Research Institute of Psychiatry - V. Serbsky National Medical Research Centre for Psychiatry and Narcology; Russian National Research Medical University. N.I. Pirogov

MD, head of the Department

Dmitry V. Gusev

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia

Email: doctor.dgusev@gmail.com
postgraduate student

Guzyal I. Tabeeva

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia

Email: 8 (495) 963-76-84.E-mail: bobrov2004@yandex.ru
PhD, senior researcher

Taisiya E. Nikitina

V. Serbsky National Medical Research Centre for Psychiatry and Narcology

Email: doctorip@mail.ru
PhD, researcher

Irina N. Agamamedova

V. Serbsky National Medical Research Centre for Psychiatry and Narcology

Email: agama6@yandex.ru
PhD, psychotherapist

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