Spontaneous ovarian hyperstimulation syndrome


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Abstract

Background. The genetic determinants of ovarian hyperstimulation syndrome (OHSS) are relevant due to the fact that the prediction of this complication by routine clinical and laboratory markers is not always objective. The emergence of spontaneous forms of the OHSS is associated just with the peculiarities of the genotype. Description. The paper presents a clinical case of OHSS in a patient with spontaneous pregnancy and shows the relationship of this condition to the OHSS risk genotypes identified in the study of genetic features of the development and course of OHSS in ART programs. Conclusion. The development of OHSS in spontaneous pregnancy and the detection of the genotype characteristics of this condition in this patient emphasize the contribution of genetics to the development of this complication and the relevance of searching for new markers to personalize ART programs. Genetic testing is a highly specific technique that can minimize the risks associated with the development of OHSS.

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About the authors

Daria A. Strelchenko

National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russian Federation

Email: da_strelchenko@mail.ru
junior researcher of the Department of Preservation and Restoration of Reproductive Function

Svetlana G. Perminova

National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russian Federation

Email: perisvet@list.ru
MD, leading researcher of the Department of Preservation and Recovery of Reproductive

Andrei E. Donnikov

National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russian Federation

Email: a_donnikov@oparina4.ru
PhD, head of the Laboratory of Molecular Genetic Methods

Irina E. Korneeva

National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russian Federation

Email: irina.korneeva@inbox.ru
MD, Department of Preservation and Recovery of Reproductive Functions

Aidar N. Abubakirov

National Medical Research Center for Obstetrics, Gynecology, and Perinatology named after Academician V.I. Kulakov, Ministry of Health of Russian Federation

Email: nondoc555@yahoo.com
PhD, head of the Department of Preservation and Restoration of Reproductive Function

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