Congenital antithrombin III deficiency and pregnancy: a description of various pregnancy management options according to international data
- Authors: Kirsanova T.V.1, Vinogradova M.A.1, Klimenchenko N.I.1
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Affiliations:
- National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia
- Issue: No 1 (2019)
- Pages: 171-177
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248478
- DOI: https://doi.org/10.18565/aig.2019.1.171-177
- ID: 248478
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Abstract
Objective. To describe various pregnancy management options according to international data in patients with congenital antithrombin (AT) III deficiency and venous thromboses occurring during pregnancy. Taking into account that the anticoagulant potential cannot be fully achieved using heparins/low-molecular-weight heparins (LMWH) alone, the authors consider other therapy approaches. Case report. The authors describe their own cases of AT III deficiency in young patients whose pregnancy has become a trigger for thrombosis; the course and outcome of pregnancies have been investigated; approaches to treating LMWH refractory thrombosis are depicted. Conclusion. AT deficiency is a rare high-risk thrombophilia. Despite the use of adequate LMWH doses during pregnancy and the postpartum period, the women with AT deficiency remain prone to venous thrombosis/ thromboembolism development or progression. There are limited and rather disparate descriptions of treatment for thrombotic events during pregnancy, including the use of antithrombin concentrates. The article summarizes current management approaches for these patients with special attention to the interdisciplinary approach.
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About the authors
Tatyana V. Kirsanova
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia
Email: A_Tatya@mail.ru
PhD, senior researcher of the Department of Reproductive Hematology and Clinical Hemostasis
Maria A. Vinogradova
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia
Email: mary-grape@ya.ru
PhD, head of the Department of Reproductive Hematology and Clinical Hemostasiology
Natalia I. Klimenchenko
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov Ministry of Health of Russia
Email: n_klimenchenko@oparina4.ru
PhD, senior researcher Department of Pregnancy Pathology
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