Clinical and molecular genetic determinants of the development of gestational diabetes mellitus


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Abstract

The molecular mechanisms of the pathogenesis of gestational diabetes mellitus (GDM) remain insufficiently studied, which is largely determined by its heterogeneous nature. The paper reviews the data available in the current literature on studies of the molecular genetic determinants of the development of gestational diabetes mellitus. It describes predictors for GDM, their relationship to obstetric and neonatal outcomes, as well as associations with other types of diabetes and with the risk of their development. Conclusion. Further investigations are needed to identify virtually significant molecular genetic biomarkers for GDM.

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About the authors

Zulfiya S. Khodzhaeva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: zkhodjaeva@mail.ru
MD, professor, head of the 1st Department of Patology of Pregnancy

Nina V. Snetkova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: E-maihn_snetkova@maH.ru
postgraduate student, 1st Department of Pathology of Pregnancy

Natalia I. Klimenchenko

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_klimenchenko@oparina4.ru
senior researcher

Mariya E. Abramova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

clinical intern

Elena I. Degtyareva

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_degtyareva@oparina4.ru
PhD, Outpatient Department

Andrey E. Donnikov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_donnikov@oparina4.ru
PhD, head of the Department of Laboratory and Genetic Methods

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