Validation of the modern concept of the development of preeclampsia


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Abstract

The article presents a modern, scientifically validated concept of the development and progression of preeclampsia. The destructive character of gestational endothelial damage in this pregnancy complication is associated with immune complex diseases. The pathogenesis of immune complex diseases involves an abnormal (excessive) activation of the complement system with the development of thrombotic microangiopathy. The authors emphasize the relationship between the time of preeclampsia onset (after 22 weeks of pregnancy) and the features of fetal organogenesis and systemogenesis, which allowed an assumption of the role of neuron-specific proteins of the developing fetal brain in immune damage to the maternal endothelium. The study findings imply the possibility of new therapeutic approaches to managing patients with preeclampsia, provide a rationale for targeted treatment modalities aimed at the most important link in the pathogenesis, which is essential in preserving maternal and child health and life.

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About the authors

Iraida S. Sidorova

I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia (Sechenov University)

Email: sidorovais@yandex.ru
MD, professor, academician of the RAS, merited scholar of the Russian Federation, merited doctor of the Russian Federation, professor at the Department of Obstetrics and Gynecology №1, Medical Faculty

Natalia A. Nikitina

I.M. Sechenov First Moscow State Medical University of Minzdrav of Russia (Sechenov University)

Email: natnikitina@list.ru
MD, professor, Department of Obstetrics and Gynecology №1, Medical Faculty

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