Association of the polymorphic variant G-105a of the SEPS1 gene and the polymorphic variant C3872T of the CRP gene with preterm birth


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Objective. To determine an association of the polymorphic variant G-105A of the SEPS1 gene and the polymorphic variant C3872T of the CRP gene with preterm birth in European women. Subjects and methods. Sixty-five women with preterm birth at 23.5 to 37 weeks’ gestation and 65 women with full-term pregnancy were genotyped. The polymorphic variant G-105A of the SEPS1 gene was determined by the polymerase chain reaction (PCR), followed by restriction analysis, the polymorphic variant C3872T of the CRP gene was done by the allele-specific PCR followed by electrophoretic detection. Results. There was an association of the polymorphic variant G-105A of the SEPS1 gene with the risk of preterm birth in Caucasian women. The frequency of the A allele of the SEPS1 gene was 20%, which was signif icantly higher than that in the control group (8%) (х2 = 5.025, p = 0.025). The incidence of heterozygotes was also considerably higher in the preterm birth group (x2 = 6.002; p = 0.014).There was no association of the T allele in the polymorphic variant C3872T of the CRP gene with preterm birth. Conclusion. The A allele in the polymorphic variant G-105A of the gene SEPS1 can act as one of the predictors of preterm birth.

Full Text

Restricted Access

About the authors

Indira O. Musalaeva

Peoples’ Friendship University of Russia

Email: i700@mail.ru
Post-graduate Student, Department of Obstetrics and Gynecology, Institute of Medicine

Ekaterina V. Tarasenko

Peoples’ Friendship University of Russia

Email: tarasenko_ev@inbox.ru
PhD (Biol.), associate professor, Department of Biology and General Genetics, Institute of Medicine

Tatyana V. Galina

Peoples’ Friendship University of Russia

Email: tatiana.galina1@mail.ru
MD, professor, Department of Obstetrics and Gynecology, Institute of Medicine

Elena M. Zheludova

Peoples’ Friendship University of Russia

Email: zheludova_em@pfur.ru
PhD (Biol.), associate professor, Department of Biology and General Genetics, Institute of Medicine

Madina M. Azova

Peoples’ Friendship University of Russia

Email: azovam@mail.ru
D.Sc. (Biol.), associate professor, head of the Department of Biology and General Genetics, Institute of Medicine

Nina P. Kirbasova

I.M. Sechenov First Moscow State Medical University

MD, professor

Anton S. Olenev

City Clinical Hospital No. 24 DZM, Perinatal Center

Email: felidis@mail.ru
PhD, head

References

  1. Всемирная организация здравоохранения. Информационные бюллетени. Available at: http://www.who.int/mediacentre/factsheets/fs363/ru/
  2. Lu G.C., Goldenberg R.L., Cliver S.P., Kreaden U.S., Andrews W.W. Vaginal fetal fibronectin levels and spontaneous preterm birth in symptomatic women. Obstet. Gynecol. 2001; 97(2): 225-8.
  3. Noguchi T., Sado T., Naruse K., Shigetomi H., Onogi A., Haruta S. et al. Evidence for activation of Toll-like receptor and receptor for advanced glycation end products in preterm birth. Mediators Inflamm. 2010; 2010: 490406. https:// dx.doi.org/10.1155/2010/490406.
  4. Allen-Daniels M.J., Serrano M.G., Pflugner L.P., Fettweis J.M., Prestosa M.A., Koparde V.N. et al. Identification of a gene in Mycoplasma hominis associated with preterm birth and microbial burden in intraamniotic infection. Am. J. Obstet. Gynecol. 2015; 212(6): 779. e1-779. e13. https://dx.doi.org/10.1016/j. ajog.2015.01.032.
  5. Wang Y., Yang X., Zheng Y., Wu Z.H., Zhang X.A., Li Q.P. et al. The SEPS1G-105A polymorphism is associated with risk of Sspontaneous preterm birth in a Chinese population. PLoS One. 2013; 8(6): e65657. https://dx.doi.org/10.1371/ journal.pone.0065657.
  6. Langmia I.M., Apalasamy Y.D., Omar S.Z., Mohamed Z. Impact of IL1B gene polymorphisms and interleukin 1B levels on susceptibility to spontaneous preterm birth. Pharmacogenet. Genomics. 2016; 26(11): 505-9. https://dx.doi. org/10.1097/FPC.0000000000000243.
  7. Sun H.Y., Liu T.B., Wang Q.C., Wu W.Q., He Y.J. Single nucleotide polymorphism in the SEPS1 gene may contribute to the risk of various human diseases: a metaanalysis. Ann. Hum. Biol. 2016; 43(5): 469-79. https://dx.doi.org/10.3109/030 14460.2015.1070903.
  8. Shahshahan Z., Iravani H. Comparison of CRP and ALK-P serum levels in prediction of preterm delivery. Adv. Biomed. Res. 2016; 5: 17. https://dx.doi. org/10.4103/2277-9175.175903.
  9. Stepan M., Cobo T., Musilova I., Hornychova H., Jacobsson B., Kacerovsky M. Maternal serum C-reactive protein in women with preterm prelabor rupture of membranes. PLoS One. 2016; 11(3): e0150217. https://dx.doi.org/10.1371/ journal.pone.0150217.
  10. Yang X., Peng W., Zhu L. N., Zhang X.A., Wang Y. Association between interleukin-1P C+3953T and genetic susceptibility to spontaneous preterm birth: a case-control study. Zhongguo Dang Dai Er Ke Za Zhi. 2016; 18(11): 1123-9.
  11. Berenguer A.G., Fernandes A.T., Oliveira S., Rodrigues M., Ornelas P., Romeira D. et al. Genetic polymorphisms and asthma: findings from a case-control study in the Madeira island population. Biol. Res. 2014; 47: 40. https://dx.doi. org/10.1186/0717-6287-47-40.
  12. Hart K., Landvik N.E., Lind H., Skaug V., Haugen A., Zienolddiny S. A combination of functional polymorphisms in the CASP8, MMP1, IL10 and SEPS1 genes affects risk of non-small cell lung cancer. Lung Cancer. 2011; 71(2): 123-9. https://dx.doi.o^/10.1016/j.lungcan.2010.04.016.
  13. Емельянова А.Н., Витковский Ю.А. Генетический полиморфизм IL-10 и CRP у больных циррозом печени вирусной этиологии. Сибирский медицинский журнал (Иркутск). 2013; 119(4): 39-41.
  14. Mao H., Cui R., Wang X. Association analysis of selenoprotein S. polymorphisms in Chinese Han with susceptibility to gastric cancer. Int. J. Clin. Exp. Med. 2015; 8(7): 10993-9.
  15. Shibata T., Arisawa T., Tahara T., Ohkubo M., Yoshioka D., Maruyama N. et al. Selenoprotein S. (SEPS1) gene -105G>A promoter polymorphism influences the susceptibility to gastric cancer in the Japanese population. BMC Gastroenterol. 2009; 9: 2. 1 https://dx.doi.org/10.1186/1471-230X-9-2.
  16. Gabay C., Kushner I. Acute-phase proteins and other systemic responses to inflammation. N. Engl. J. Med. 1999; 340(6): 448-54.
  17. dbSNP https://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?geneId=1401
  18. Царенок С.Ю., Горбунов В.В., Дутова А.А. Частота аллелей и генотипов полиморфизма гена C-реактивного белка у женщин с ишемической болезнью сердца и постменопаузальным остеопорозом. Тихоокеанский медицинский журнал. 2017; 4: 65-8.
  19. Емельянов А. С., Витковский Ю.А., Емельянова А.Н. Частота аллелей и генотипов полиморфизма гена CRP (C3872T) при первичной роже. Забайкальский медицинский вестник. 2015; 4: 135-7.
  20. R Core Team (2013). R: A language and environment for statistical computing. R. Foundation for Statistical Computing, Vienna, Austria. Available at: http://www.R-project.org
  21. Wang J., Shete S. Testing departure from Hardy-Weinberg proportions. Methods Mol. Biol. 2012; 850: 77-102. https://dx.doi.org/10.1007/978-1-61779-555-8_6.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies