The features and efficiency of therapy for uncomplicated cystitis in pregnant women and puerperas


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Abstract

Objective. To investigate the features of therapy and to evaluate its efficiency for acute uncomplicated cystitis in pregnant women andpuerperas. Matetials and methods. The investigation enrolled 46 pregnant women and 10 puerperas with acute uncomplicated cystitis. All the patients underwent clinical and laboratory examination and received therapy with fosfomycin trometamol at a single 3-g dose. Results. Fosfomycin demonstrated a significant efficacy: there was regression of clinical symptoms in 96.4% of the patients and complete pathogen elimination in 94.6%; there were no recurrent cystitis at a 3-month follow-up after therapy. Neither side effects nor adverse reactions were found; a high compliance to therapy was noted. Conclusion. The first-line empirical treatment of acute uncomplicated cystitis in pregnant women and puerperas is single-dose fosfomycin trometamol that exceeds antibacterial drugs in a long-term dosage regimen in terms of convenience of use.

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About the authors

Vladimir N. Serov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: v_serov@oparina4.ru
MD, professor, academician of the Russian Academy of Sciences, chief researcher

Anna A. Balushkina

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: ann.balushkina@gmail.com
PhD, researcher

Victor L. Tyutyunnik

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: tioutiounnik@mail.ru
MD, professor, the head of the Obstetric Physiological Department

Natalia E. Kan

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: kan-med@mail.ru
MD, professor, Department of Obstetrics and Gynecology

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