The use of autoplasma, enriched with platelet-derived soluble factors, when carrying out the programs of in vitro fertilization (IFV) in patients with infertility and chronic endometritis
- Authors: Doronina O.K.1, Deilidka E.N.2
-
Affiliations:
- Federal State Budget Institution "National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov" Ministry of Health of the Russian Federation
- Healthcare Institution "Clinical Maternity Hospital № 2"
- Issue: No 7 (2019)
- Pages: 72-76
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248549
- DOI: https://doi.org/10.18565/aig.2019.7.%2072%20-76
- ID: 248549
Cite item
Open Access
Access granted
Abstract
Aim of study: To evaluate the effectiveness of autoplasma enriched with platelet-derived soluble factors in IVF cycles in patients with chronic endometritis in history. Materials and methods: The study took place in the period from 2017 to 2018. In IVF cycle autoplasma was not injected into the patients in Group I (n=43); on the 6th-10th day of the stimulated cycle, autoplasma enriched with platelet-derived soluble factors was injected into uterus in patients in group II (n=94). Inclusion criteria: the patients of reproductive age with infertility and chronic endometritis in history. Exclusion criteria: the patients with poor embryo quality. Results: Intrauterine injection of autologous plasma enriched with platelet-derived soluble factors increases up to 25% the success rate of embryo implantation during IVF procedure, as compared to traditional protocols.
Full Text
About the authors
Olga K. Doronina
Federal State Budget Institution "National Medical Research Center of Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov" Ministry of Health of the Russian Federation
Email: o_doronina@oparina4.ru
MD, Professor, Deputy Head of Medical Care Organization
Ella N. Deilidka
Healthcare Institution "Clinical Maternity Hospital № 2"
Email: deilidka@gmail.com
postgraduate student
References
- Спирина Ю.В., Евтушенко И.Д. Подготовка пациенток, страдающих хроническим эндометритом, к программам вспомогательных репродуктивных технологий. Сибирский медицинский журнал. 2008; 23(4): 84-6
- Takebayashi A., Kimura F., Kishi Y., Ishida M., Takahashi A. et al. The association between endometriosis and chronic endometritis. PLoS One. 2014; 9(2): e88354. https://doi.org/10.1371/journal.pone.0088354.
- Сухих Г.Т., Чернуха Г.Е., Табеева Г.И., Горюнов К.В., Силачев Д.Н. Современные возможности клеточной терапии синдрома Ашермана. Акушерство и гинекология. 2018; 5: 20-8.
- Маринкин И.О., Трунченко Н.В., Волчек А.В., Агеева Т.А., Никитенко Е.В., Макаров К.Ю., Кулешов В.М., Омигов В.В., Айдагулова С.В. Маркеры воспаления в нормальном и тонком эндометрии при хроническом эндометрите. Акушерство и гинекология. 2018; 2: 65-73.
- Kitaya K., Yasuo T. Immunohistochemistrical and clinicopathological characterization of chronic endometritis. Am. J. Reprod. Immunol. 2011; 66(5): 410-5. https://doi.org/10.1111/j.1600-0897.2011.01051.x.
- Lessey B.A. Two pathways of progesterone action in the human endometrium: implications for implantation and contraception. Steroids. 2003; 68(10-13): 809-15.
- Pietrzak W.S., Eppley B.L. Platelet rich plasma: biology and new technology. J. Craniofac. Surg. 2005; 16(6): 1043-54.
- Zadehmodarres S., Salehpour S., Saharkhiz N., Nazari L. Treatment of thin endometrium with autologous platelet-rich plasma: A pilot study. JBRA Assist. Reprod. 2017; 21(1): 54-6. https://doi.org/10.5935/ 1518-0557.20170013.
- Nazari L., Salehpour S., Hoseini S., Zadehmodarres S., Ajori L. Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: A pilot study. Int. J. Reprod. Biomed. 2016; 14(10): 625-8.
- Marini M.G., Perrini C., Esposti P., Corradetti B., Bizzaro D., Riccaboni P. et al. Effects of platelet-rich plasma in a model of bovine endometrial inflammation in vitro. Reprod. Biol. Endocrinol. 2016; 14(1): 58-75. https://doi.org/10.1186/ s12958-016-0195-4.
- Polisseni F., Bambirra E.A., Camargos A.F. Detection of chronic endometritis by diagnostic hysteroscopy in asymptomatic infertile patients. Gynecol. Obstet. Invest. 2003; 55(4): 205-10. https://doi.org/10.1159/000072075.
- Доронина О.К., Дейлидко Э.Н., Мордус О.Н. Применение плазмы, обогащенной растворимыми факторами тромбоцитов, у женщин в циклах ЭКО. Медицинский журнал. 2018; 4: 53-7.
Supplementary files
