Association between the 657T>C polymorphism of the chromosome segregation gene SYCP3 and idiopathic recurrent pregnancy loss in the Kazakh population
- Authors: Svyatova G.S.1, Berezina G.M.1, Murtazalieva A.V.1
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Affiliations:
- JSC Research Center for Obstetrics, Gynecology, and Perinatology
- Issue: No 12 (2019)
- Pages: 105-110
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248687
- DOI: https://doi.org/10.18565/aig.2019.12.105-110
- ID: 248687
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Abstract
Aim. To investigate the association between the 657T>C polymorphism of the synaptonemal complex SYCP3 gene (rs769825641) and the development of idiopathic recurrent pregnancy loss (iRPL) in ethnically homogeneous Kazakh population. Material and methods. Three thousand two patients with iRPL and 300 women with normal reproductive function underwent independent replicative TagMan genotyping. Results. The study findings support the association between the studied polymorphism and the development of iRPL in the Kazakh population. The frequency of carrying the unfavorable C allele in the study group (3,97%) was significantly higher than in women with normal reproduction function (2,0%) (x2 = 4, 04; p < 0.05). Conclusions. Synaptonemal complex proteins play an important role in regulating meiosis in iRPL, suggesting the possibility of considering the studied polymorphism as a possible genetic risk factor for iRPL of unknown cause.
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About the authors
Gulnara S. Svyatova
JSC Research Center for Obstetrics, Gynecology, and Perinatology
Email: gsvyatova1@mail.ru
Galina M. Berezina
JSC Research Center for Obstetrics, Gynecology, and Perinatology
Email: gberezina54@mail.ru
Alexandra V. Murtazalieva
JSC Research Center for Obstetrics, Gynecology, and Perinatology
Email: alexmurtazalieva@gmail.com
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