PREPARATION FOR THE IN VITRO FERTILIZATION TREATMENT OF INFERTILITY IN DIMINISHED OVARIAN RESERVE- PRE-IVF TIDOR


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Abstract

Objective. To assess the quality of oocytes, embryos, and outcomes of in vitro fertilization (IVF) cycles in patients with diminished ovarian reserve (OR) who received inositol before infertility treatment. Subjects and methods. An observational comparative multicenter study pre-IVF TIDOR included 270patients. Group 1 (n=158) took inositol 4000 mg + folic acid 400цg (Inofert, Italfarmaco S.p.A., Italy); Group 2 (n=112) did not receive inositol before infertility treatment using IVF. The inclusion criteria were age <38years; a history of ovarian surgery; AMH <1.0 pg/ml, transfer of 42 embryos (ET) in the ovarian stimulation (OS) cycle. Results. In Group 1 and Group 2, mature oocytes (n=5 (0-7) and 2 (0- 5); p = 0.049) and good- quality embryos (42.2 and 30.1%; p = 0.049) were retrieved; there was a high rate of ET-induced pregnancy (38.1and 30.0%; p = 0.041). Conclusion. It is expedient to use inositol (Inofert, Italfarmaco S.p.A., Italy) in women younger than 38years after ovarian surgery in order to enhance the efficiency of IVF.

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About the authors

Emma Vramovna Vartanyan

OOO «Test-Tube Baby» Clinic for Assisted Reproductive Technologies; N.I. Pirogov Russian National Research Medical University, Ministry of Health of Russia

MD, professor of the Department of Obstetrics and Gynecology; President of the selfregulating society Association 117997 Russia, Moscow, Ostrovitianov str., 1. 123182 Russia, Moscow, Schukinskaya str., 2

Kristina Ashotovna Tsaturova

OOO «Test-Tube Baby» Clinic for Assisted Reproductive Technologies

MD, chief physician 117997 Russia, Moscow, Ostrovitianov str., 1. 123182 Russia, Moscow, Schukinskaya str., 2

Ekaterina Aleksandrovna Devyatova

OOO «Test-Tube Baby» Clinic for Assisted Reproductive Technologies

Email: devyatova@baby-ivf.ru
PhD, doctor of ultrasound diagnostics, obstetrician-gynecologist 117997 Russia, Moscow, Ostrovitianov str., 1. 123182 Russia, Moscow, Schukinskaya str., 2

A. S Mikhaylyukova

OOO «Test-Tube Baby» Clinic for Assisted Reproductive Technologies

obstetrician-gynecologist, reproductologist 117997 Russia, Moscow, Ostrovitianov str., 1. 123182 Russia, Moscow, Schukinskaya str., 2

V. A Levin

OOO «Test-Tube Baby» Clinic for Assisted Reproductive Technologies

endocrinologist 117997 Russia, Moscow, Ostrovitianov str., 1. 123182 Russia, Moscow, Schukinskaya str., 2

K. Y Sagamonova

OOO «Center for Human Reproduction and IVF»

344068 Russia, Rostov-on-Don, Bodraya str., 90А

D. S Gromenko

OOO «ANEKO»

MD, director 450029 Russia, Republic of Bashkortostan, Ufa, Puteyskaya str., 2

T. V Ovsyannikova

New Medical Technologies Clinic, OOO «Personalized Medicine Center», Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences

MD, chief physician 630090 Russia, Novosibirsk, Pirogov str., 25/4

N. M Erlihman

«Istochnik» (Source) IVF Clinic

PhD, obstetrician-gynecologist, reproductologist, doctor of ultrasound diagnostics 454100 Russia, Chelyabinsk, Chicherina str., 36B

E. A Kolosova

ZAO «Malysh» (Baby) Medical Center

chief of the Medical Department 625002 Russia, Tumen, Sverdlov str., 35-la

E. V Safronova

OOO «IVF» Reproductive Health Clinic

PhD, obstetrician-gynecologist, reproductologist 443030 Russia, Samara, K. Marx av., 6

O. V Fotina

OOO «Filosofiya Zhizni» (Philosophy of Life)

chief physician 614107 Russia, Perm, Kim str., 64

E. V Krasnovskaya

OOO «Tonus Mama»

chief physician 603000 Russia, Nizhny Novgorod, Vorovsky str., 22

L. G Pozharischenskaya

OOO «Genesis Clinic»

chief of the Department 295026 Russia, Crimea Republic, Simferopol, Semashko str., 4

S. R Autleva

OOO «Kuban Medical Center»

PhD, obstetrician-gynecologist, reproductologist 350072 Russia, Krasnodar, Moskovskaya str., 65

A. M Gzgzyan

D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology

MD, professor of the Department of Obstetrics, Gynecology and Reproductology l99034 Russia, Saint-Petersburg, Mendeleev Line, 3

I. R Nuriev

OOO «Nureevs Clinic», Clinical Medical Diagnostic Center

director 420110 Russia, Kazan, Kasimovs’ Brothers str., 40a

E. E Voropaeva

OOO «Infertility Treatment Center»

MD, chief physician 454048 Russia, Chelyabinsk, Yablochkina str., 3

T. I Pestova

ZAO «Family Medicine Center»

PhD, chief physician 454021 Russia, Chelyabinsk, Logovaya str., 13

V. M Zdanovsky

OOO «Professor V.M. Zdanovsky Clinic»

MD, professor, director 115191 Russia, Moscow, Holodilny 2-2

N. A Kim

OOO «Perm Mother and Child»

PhD, obstetrician-gynecologist, reproductive specialist 614000 Russia, Perm, Ekaterininskaya str., 64

A. N Kotelnikov

OOO «Genome-Volga»

PhD, director 400078 Russia, Volgograd, Lenin av., I02A

O. V Safronov

South Ural State Medical University, Ministry of Health of Russia

PhD., associate Professor, head of the Department of obstetrics and gynecology IPDO 454092, Russia, Chelyabinsk,Vorovskogo str., 64

T. A Nazarenko

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

MD, professor, director of the institute reproductive medicine 117997 Russia Moscow, Ac. Oparina str., 4

R. M Ionova

Stavropol State Medical University, Ministry of Health of Russia

PhD., assistant of the Department of Obstetrics and Gynecology 355017, Stavropol, ul. Mira, d. 310

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