The first Russian experience with controlled mechanical microvibration in growing human embryos in assisted reproductive technology programs


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Abstract

Objective. To evaluate the impact of controlled mechanical microvibration of human embryos during the first five days of development on pregnancy rates in assisted reproductive technology (ART) programs. Subjects and methods. The investigation enrolled 75 (a microvibration group) and 300 (a control group) married couples without contraindications or complications developed during ART programs. During cultivation under mechanical microvibration, the incubator was placed on an ArisTT180-s platform (K&S Advanced Systems Ltd, Israel) in the active vibration mode with a frequency of 40 Hz for 30 seconds at a rest interval of 30 minutes. Results. The pregnancy rate per ovarian stimulation cycle was 42.7% (n = 32) in the microvibration group versus 33.7% (n = 101) in the control group (p = 0.09). The pregnancy rate per embryo transfer was 50.8 and 40%, respectively (p = 0.097). Conclusion. The use of controlled mechanical microvibration to grow embryos can significantly increase pregnancy rates in ART programs.

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About the authors

Andrey Yu. Romanov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: romanovl553@yandex.ru

Alexandra M. Frolova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: i.a.m.frolova@mail.ru

Nataliya P. Makarova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: np_makarova@oparina4.ru

Nataliya V. Dolgushina

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_dolgushina@oparina4.ru

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