Features of karyotypes in married couples with reproductive functional problems in Kazakhstan


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Abstract

Objective. To investigate the frequency and spectrum of chromosomal abnormality and chromosomal polymorphism in married couples with reproductive functional problems to determine the etiology of infertility, treatment policy, and prognosis in offspring. Subjects and methods. A cytogenetic study of peripheral blood lymphocytes was performed in 1524 patients (672 married couples with infertility and miscarriage, 90 men and 90 women without reproductive problems) at the PERSONA International Clinical Center of Reproductology in 2017 to 2018. Results. The chances of detecting chromosomal polymorphism in patients with infertility and burdened obstetric history (BOH) were higher than in those with normal reproduction (OR = 28.896, 95% CI, 11.799-70.765 for women; OR = 29.000, 95% CI, 9.081-92.611for men; p < 0.05). Conclusion. Our data allow us to recommend that genetic studies must be included in the diagnostic algorithms and clinical protocols for assisted reproductive treatment for patients with reproductive functional problems in the Republic of Kazakhstan.

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About the authors

Irina G. Khoroshilova

PERSONA International Clinical Center for Reproductology; Research Center of Obstetrics, Gynecology, and Perinatology

Email: ira_horoshilova@mail.ru
MD, student PhD, Center for Obstetrics, Gynecology and Perinatology 050020, Republic of Kazakhstan, Almaty, Dostyk Ave,125

Vyacheslav N. Lokshin

PERSONA International Clinical Center for Reproductology

Email: v_lokshin@persona-ivf.kz
MD, professor, corresponding member NAS RK, President of the Kazakhstan Association of Reproductive Medicine, President of the International Academy of Reproductology, General Director 050060, Republic of Kazakhstan, Almaty, Utepova, 32A

Aymira A. Begimbaeva

PERSONA International Clinical Center for Reproductology

Email: aimira.begimbayeva@mail.ru
cytogenetics doctor 050060, Republic of Kazakhstan, Almaty, Utepova, 32A

Zhadyra K. Sarsenbaeva

PERSONA International Clinical Center for Reproductology

Email: zhadyradada@gmail.com
doctor of cytogenetics 050060, Republic of Kazakhstan, Almaty, Utepova, 32A

Ravil K. Valiev

PERSONA International Clinical Center for Reproductology

Email: rvaliev75@mail.ru
PhD, associate professor, head physician 050060, Republic of Kazakhstan, Almaty, Utepova, 32A

Anastassiya N. Rybina

PERSONA International Clinical Center for Reproductology

Email: oedema@mail.ru
MPh, reproductologist 050060, Republic of Kazakhstan, Almaty, Utepova, 32A

Sholpan K. Karibaeva

PERSONA International Clinical Center for Reproductology

Email: sh.karibaeva@gmail.com
PhD, associate professor, deputy general director 050060, Republic of Kazakhstan, Almaty, Utepova, 32A

Alyena V. Kim

Al-Farabi Kazakh National University

Email: alyena982401@gmail.com
student of the Faculty of Biology and Biotechnology 050040, Republic of Kazakhstan, Almaty, al-Farabi Ave, 71

Nadezhda Yu. Semenova

Al-Farabi Kazakh National University

Email: grebenchshikova.nadezhda@gmail.com
student of the Department of Biology and Biotechnology 050040, Republic of Kazakhstan, Almaty, al-Farabi Ave, 71

References

  1. Локшин В.Н., Джусубалиева Т.М., ред. Клиническая практика в репродуктивной медицине. Алматы: MedMedia Казахстан, 2015. 464 с. ISBN 978-601-80151-6-82015.
  2. Сидельникова В.М., Сухих Г.Т. Невынашивание беременности. М.: МИА; 2010. 536 с.
  3. Локшин В.Н., Хорошилова И.Г., Куандыков Е.У. Персонифицированный подход при генетическом скрининге супружеских пар в программах ВРТ (Обзор литературы). Доклады Национальной Академии наук Республики Казахстан. 2018; 1: 37-41. ISSN 2518-1483.
  4. Гончарова Н.Н., Мартышкина Е.Ю., Казначеева Т.В., Арсланян К.Н., Адамян Л.В., Курило Л.Ф., Сорокина Т.М., Черных В.Б. Медикогенетические аспекты бесплодия. Акушерство. Гинекология. Репродукция. 2012; 6(2): 35-40. eLIBRARY ID: 17901152
  5. Баранов В.С., Кузнецова Т.В. Цитогенетика эмбрионального развития человека. СПб.: Н-Л; 2006. 640 с.
  6. Фетисова И.Н., Дюжев Ж.А., Конева Т.Г., Липин М.А. Цитогенетические факторы первичного бесплодия и привычной потери беременности. Вестник новых медицинских технологий. 2008; 15(1): 43-4.
  7. Kovaleva N.V. Examination of Rates and Spectrums of Robertsonian Translocations in the General Population and in Patients with Reproductive Disorders. Rus J Genet. 2018; 54(4): 489-93. doi: 10.1134/S1022795418040099
  8. Scriven P.N., Flinter F.A., Braude P. R., Mackie Ogilvie C. Robertsonian translocations--reproductive risks and indications for preimplantation genetic diagnosis. Hum Reprod. 2001; 16(11): 2267-73. doi: 10.1093/humrep/16.11.2267
  9. Uehara S., Akai Y., Takeyama Y., Takabayashi T., Okamura K., Yajima A. Pericentric Inversion of Chromosome 9 in Prenatal Diagnosis and Infertility. J Exp Med. 1992; 166(4): 417-27. doi: 10.1620/tjem.166.417
  10. Sahin F.I., Yi lmaz Z, Yuregir O.O., Bulakbasi T., Ozer O., Zeyneloglu H.B. Chromosome heteromorphisms: an impact on infertility. J Assist Reprod Gen. 2008; 25(5):191-5. doi: 10.1007/s10815-008-9216-3
  11. Caglayan A.O., Ozyazgan I., Demiryilmaz F., Ozgun M.T. Are heterochromatin polymorphisms associated with recurrent miscarriage? J Obstet Gynecol Res. 2010; 36(4): 774-6. doi: 10.1111/j.1447-0756.2010.01207.x
  12. Madon P.F., Athalye A.S., Parikh F.R. Pоlymorphic variants on chromosomes probably play a significant role in infertility. Reprod Biomed Online. 2005; 11(6): 726-32. doi: 10.1016/S1472-6483(10)61691-4
  13. Minocherhomji S., Athalye A.S., Madon P.F., Kulkarni D., Uttamchandani S.A., Parikh F.R. A case-control study identifying chromosomal polymorphic variations as forms of epigenetic alterations associated with the infertility phenotype. Fertil Steril. 2009; 92(1): 88-95. doi: 10.1016/j.fertnstert.2008.05.071
  14. Li L.L., Peng D., Wang R.X., Zhu H.B., Wang W.J., Liu R.Z. Correlation between chromosomal polymorphisms and male infertility in a Northeast Chinese population. Genet. Mol. Res. 2015; 14 (4): 15435-5443. doi: 10.4238/2015.November.30.21
  15. Cheng R., Ma Y., Nie Y., Qiao X., Yang Z., Zeng R., Xu L.Chromosomal polymorphisms are associated with female infertility and adverse reproductive outcomes after infertility treatment: a 7-year retrospective study. Reprod Biomed Online. 2017; 35(1): 72-80. doi: 10.1016/j.rbmo.2017.03.022.
  16. Овчинников Р.И., Гамидов С.И., Попова А.Ю., Ушакова И.В., Голубева О.Н. Привычное невынашивание беременности - что зависит от мужчины? Акушерство и гинекология. 2016; 12: 15-23. (in Russian)]. http://dx.doi.org/10.18565/aig.2016.12.15-23
  17. Yakin K., Balaban B., Urman B. Is there a possible correlation between chromosomal variants and spermato-genesis? Int J Urol. 2005; 12(11): 984-9. doi: 10.1111/j.1442-2042.2005.01185.x
  18. Saran N., Kumar B., Kumar A. Chromosomal Heteromorphisms and Karyotype Abnormalities in Humans. Int J Curr Microbiol App Sci. 2017; 6(5): 2940-53 https://doi.org/10.20546/ijcmas.2017.605.333
  19. Morales R., Liedo B., Ortiz J., Ten J., Llacer J., Bernabeu R. Chromosomal polymorphic variants increase aneuploidies in male gametes and embryos. Syst Biol Reprod Med. 2016; 62(5): 317-24. doi: 10.1080/19396368.2016.1212949

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