The use of Elecsys PlGF and sFlt-1 test systems to predict perinatal outcomes in patients with severe preeclampsia


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Abstract

Objective. To find a threshold level for soluble fms-like tyrosine kinase-1 (sFlt-1)/placental growth factor placental growth factor (PlGF) and serum sFlt-1/PlGF ratios as predictors of poor perinatal outcomes in patients with severe preeclampsia. Subjects and methods. The investigation enrolled 28 pregnant women with severe preeclampsia. According to perinatal outcomes, all the patients were divided into 3 groups: 1) 5 patients with perinatal losses; 2) 7patients without the latter, but with intermediate perinatal outcomes (Apgar scores of less than or equal to 7 at five minutes; a neonatal umbilical cord pH less than 7.2 at birth; a lactate level greater than or equal to 4.8); 3) 16 patients without losses with favorable perinatal outcomes (Apgar scores of more than 8 at five minutes; an umbilical cord pH more than or equal to 7.2 at birth; and a lactate level less than 4.8). Results. The level of sFlt-1/PlGF was statistically significantly higher in the patients with perinatal losses than in those in Groups 2 and 3 [1162 (940-1276) vs 277(233-335) and 137(120-396)]. In Group 1, the PlGFscore was lower than in the intermediate and favorable perinatal outcome groups [15 (13-17) vs 75 (44-112) and 68 (32-78), respectively]. There were no group differences in the serum concentration of sFlt-1. Conclusion. Determination of the sFlt-1/PlGF ratio and the serum concentration of PlGF can be used as a predictor of poor perinatal outcomes. The threshold level for the sFLt-1/PlGF ratio for predicting perinatal losses was 1197, with a sensitivity of 60% and a specificity of 96%. Estimation of the sFlt-1/PlGF ratio is an additional tool not only for diagnosing preeclampsia and for determining the severity of PE, but also for defining the time of delivery in order to prevent poor perinatal complications.

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About the authors

M. A Kurtser

Russian National Research Medical University named after N.I. Pirogov; Group of Companies "Mother and Child”

Academician of the Russian Academy of Sciences, Professor, Head of the Department of Obstetrics and Gynecology of the Pediatric Faculty, CEO of the Group of Companies “Mother and Child” Moscow, Russian Federation

M. B Shamanova

Russian National Research Medical University named after N.I. Pirogov

Email: m.shamanova@mcdinics.ru
Head of the Laboratory Service Moscow, Sevastopolsky Avenue, 24, k1

O. V Sinitsina

Russian National Research Medical University named after N.I. Pirogov

Email: o.sinitsina@mcclinics.ru
Head of the Clinical Diagnostic Laboratory Moscow region, Odintsovo district, 1st Uspenskoe highway, village Lapino, 111

A. A Nikolaev

Russian National Research Medical University named after N.I. Pirogov

Email: a.nicolaev@mcclinics.ru
Head of the Clinical Diagnostic Laboratory Moscow region, Odintsovo district, 1st Uspenskoe highway, village Lapino, 111

E. V Nikolaeva

Russian National Research Medical University named after N.I. Pirogov

Email: e.nikolaeva@mcclinics.ru
Head of the Clinical Diagnostic Laboratory Moscow, Sevastopolsky Avenue, 24, k1

A. I Dedlovskaya

Russian National Research Medical University named after N.I. Pirogov

Email: a.dedlovskaya@mcclinics.ru
doctor obstetrician-gynecologist Moscow, Sevastopolsky Avenue, 24, k1

M. A Samsonova

Russian National Research Medical University named after N.I. Pirogov

Email: ma.samsonova@mcclinics.ru
Clinical Resident Moscow, Sevastopolsky Avenue, 24, k1

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