The feasibility of fertility-sparing treatment of young patients with recurrent endometrial cancer


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Abstract

Endometrial cancer is the most prevalent gynecological cancer. About 2.9-14.4% of patients with endometrial cancer are aged below 40, and the incidence of cancer in this age group is on the rise. Most cases of endometrial cancer in women of this age are diagnosed at an early stage with no myometrial invasion and lymph node involvement. Therefore, such patients have a high cure rate, and for them, a quality of life is an extremely important outcome after treatment. Fertility preservation is one of the most important issues of long-term quality of life of cancer survivors of childbearing age. Presentation A 33-year-old woman T. first presented with complaints of heavy menstrual bleeding. Her diagnostic evaluation included hysteroscopy and fractional curettage with a sampling of both the endometrial and the endocervical mucosa. Histopathological study revealed highly differentiated endometrial adenocarcinoma. Taking into account the patient’s age, nulliparous status and her desire to preserve fertility, conservative treatment was initiated. Conclusion Conservative fertility-sparing treatment is highly effective in young patients with stage IA and G1 primary and recurrent endometrial adenocarcinoma. This treatment modality is safe and effective when applied to patients who met indications and most likely to comply with planned therapy.

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About the authors

Nataliya A. Babaeva

Russian Scientific Center of Roentgeno-Radiology of Minzdrav of Russia

Email: natbabaeva@yandex.ru

Irina B. Antonova

Russian Scientific Center of Roentgeno-Radiology of Minzdrav of Russia

Email: iran24@yandex.ru

Svetlana V. Ivashina

Russian Scientific Center of Roentgeno-Radiology of Minzdrav of Russia

Email: s.ivashina@bk.ru

Olga I. Aleshikova

Russian Scientific Center of Roentgeno-Radiology of Minzdrav of Russia

Email: olga.aleshikova@gmail.com

Anna Valeryevna Lyustik

Russian Scientific Center of Roentgeno-Radiology of Minzdrav of Russia

Levon A. Ashrafyan

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia; Russian Scientific Center of Roentgeno-Radiology of Minzdrav of Russia

Email: levaa2004@yahoo.com

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