Role of the products of oocyte and embryo metabolism in patients with external genital endometriosis in successful embryo implantation


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Abstract

Objective. To present an update on the analysis of the metabolomics profile of follicular fluid and embryo culture media in patients with external genital endometriosis and on the possible use of a number of metabolites as markers for successful implantation. Materials and methods. The review includes data from foreign and Russian articles found in Pubmed on this topic over the past 10 years. Results. Follicular fluid and culture media for embryos of various development stages are unique objects of study, as they carry information about the peculiarities of the metabolic activity of oocytes and embryos. These studies will be able to identify and introduce additional methods for individualized embryo selection, which will improve outcomes, including those in women with external genital endometriosis. Conclusion. Further investigations and evaluation of the components of follicular fluid and embryo culture media in patients with external genital endometriosis are a promising area in searching for markers for successful embryo implantation with the subsequent development of clinical pregnancy and the birth of a healthy baby. Evidence-based data on the composition of follicular fluid and culture media can let one develop an additional non-invasive method for choosing an embryo for selective transfer and to elaborate an individual management algorithm for women with external genital endometriosis in assisted reproductive technology programs.

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About the authors

V. Yu Smolnikova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: v_smolnikova@oparina4.ru
PhD, Leading researcher, Department of assistive technologies in infertility treatment Academica Oparina st. 4, 117997, Moscow, Russia

L. K Ibragimova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: ibragimova_luisa0693@mail.ru
post-graduate student, Department of assistive technologies in infertility treatment Academica Oparina st. 4, 117997, Moscow, Russia

M. Yu Bobrov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: mbobr@mail.ru
M.Y., PhD in Chemistry, Head of the Laboratory of Molecular Pathophysiology, Department of Systemic Biology in Reproduction Academica Oparina st. 4, 117997, Moscow, Russia

E. A Romanov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: e_romanov@oparina4.ru
embryologist, Department of assistive technologies in infertility treatment Academica Oparina st. 4, 117997, Moscow, Russia

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