Clinical and diagnostic significance of genetic predisposition to preeclampsia in the Kazakh population


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Abstract

Objective. To study the relationship ofFactor V(FV) (rs6025), FII(rs1799963), MTHFR (rs1801133, rs1801131), MTRR (rs1801394), MTR (rs1805087), eNOS3 (rs1799983), ACE (rs4340), AGTR1 (rs5186), and ApoS3 (rs5128) polymorphisms to the development of preeclampsia in the homogeneous ethnic Kazakh population. Subjects and methods. Independent replicative TaqMan genotyping was carried out in 205pregnant and puerperal women with preeclampsia and 300pregnant and puerperal women with uncomplicated pregnancy. Results. The performed study revealed a statistically significant association (p <0.002) of the studied SNPs with the development of preeclampsia in the Kazakh population according to the folate metabolism genes: MTHFR (A1298C) and MTR (A2756G); the coagulation system gene: FII (G20210A); the aldosterone-renin-angiotensin system genes: AGTR1 (A1166C), eNOS3 (Glu298Asp), and ACE (I/D); the lipid metabolism gene: ApoC3 (G5163C). Conclusion. The found associated gene polymorphisms can be regarded as possible genetic factors for preeclampsia in the Kazakh population.

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About the authors

Dinara D. Mirzakhmetova

Research Center of Obstetrics, Gynecology, and Perinatology

Email: d.mirzakhmetova@mail.ru
Almaty, Kazakhstan

Gulnara S. Svyatova

Research Center of Obstetrics, Gynecology, and Perinatology

Email: gsvyatoval@mail.ru
Almaty, Kazakhstan

Galina M. Berezina

Research Center of Obstetrics, Gynecology, and Perinatology

Email: gberezina54@mail.ru
Almaty, Kazakhstan

Alexandra V. Murtazaliyeva

Research Center of Obstetrics, Gynecology, and Perinatology

Email: alexmurtazalieva@gmail.com
Almaty, Kazakhstan

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