Plasma levels of soluble E-cadherin and the keratinocytes growth factor in intrauterine growth restriction


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Abstract

Aim. To investigate plasma levels of soluble E-cadherin (sE-cad) and the keratinocytes growth factor (KGF) in women with fetal growth restriction (FGR). Materials and methods. The study included 25pregnant women with fetal growth restriction and 19 women with a healthy pregnancy. Plasma levels of sE-cad and KGF were determined by ELISA. Results. In women with FGR, the plasma level of sE-cad was decreased (p=0.006), while the KGF level was increased (p=0.037). ROC analysis assessing the diagnostic accuracy of sE-cad and KGF showed the AUC of 0.74 and 0.69, respectively. A low plasma level of sE-cad in women with FGR reflects impaired mobility and proliferative activity of trophoblast cells. In growth-restricted pregnancy, higher levels of KGF, as a proliferation factor, may be associated with the activation of compensatory mechanisms aimed to improve trophoblast cell proliferation. Conclusion. Plasma levels of sE-cad and KGF in pregnant women reflect the underlying pathological process interfering with the healthy growth of the placenta and may, therefore, be used as markers offetal growth restriction.

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About the authors

Aleksey M. Krasnyi

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: alexred@list.ru
Ph.D. (bio.sci.), Head of the Cytology Laboratory

Anuta A. Khachaturyan

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: x.anyt37@mail.ru
Ph.D. Student

Valentina V. Vtorushina

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: v_vtorushina@oparina4.ru
Ph.D., Laboratory Physician at the Laboratory of Clinical Immunology

Lubov V. Krechetova

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: l_krechetova@oparina4.ru
PhD, MD(Medicine), Head of the laboratory of clinical immunology

Natalia E. Kan

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia; European Medical Center

Email: kan-med@mail.ru
Dr.Med.Sci., Head Physician of the Perinatal Center of European Medical Center, Professor at the Department of Obstetrics and Gynecology

Victor L. Tyutyunnik

European Medical Center

Email: tioutiounnik@mail.ru
Dr.Med.Sci., Deputy Head Physician

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