Prediction and prevention of preeclampsia in the city Center for family planning and reproduction


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Objective. To analyze the prediction and prevention of preeclampsia using prenatal screening performed in the City Center for Family Planning and Reproduction. Materials and methods. A total of2374 case histories were analyzed. The study revealed 209 women at high risk for preeclampsia with likelihood of its developing 1:100 and higher. Additionally, 102 patients with a low risk for preeclampsia and 18 pregnant women who had severe preeclampsia at different gestation periods were identified. Results. The incidence of preeclampsia was 10.0%; it was 11.8% in the absence of preventive measures, and it was 9.7% in their presence (p=0.72). In case of hemodynamic disorders in the uterine arteries, the incidence of preeclampsia was 12.5%, in the absence of disorders it was 9.1%; the incidence was 6.7% with changes in pAPPA-A and 7.1% with changes in PLGF. Conclusion. The criteria proposed in the program are not absolute and finalized. For the prevention of preeclampsia, it is more appropriate to use a preventive complex including general hygiene measures, diet, treatment of extragenital pathology, and administration of medications depending on the detected changes.

Full Text

Restricted Access

About the authors

Raisa I. Shalina

Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: raisa.shalina@gmail.com
Doctor of Medical Sciences, professor, Professor of the Department of Obstetrics and Gynecology, Pediatric Faculty

Nigyar K. Kasumzade

Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: nk260590@gmail.com
obstetrician-gynecologist, postgraduate Department Obstetrics and Gynecology, Pediatric Faculty

Aleksandr G. Konoplyannikov

Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: npo.med@gmail.com
Doctor of Medical Sciences, Professor, Department of Obstetrics and Gynecology

Oleg A. Latyshkevich

Centre for Family Planning and Reproduction, Moscow Department of Health

Email: latishkevich@mail.ru
Head physician of GBUZ “CPS” DZM, PhD, assistant of the Department of Obstetrics and Gynecology, Pediatric Faculty

Dmitriy B. Shekhovtsov

Centre for Family Planning and Reproduction, Moscow Department of Health

Email: dr.dbs@yandex.ru
obstetrician-gynecologist

References

  1. Адамян Л.В., Артымук Н.В., Башмакова Н.В., Белокринницкая Т.У., Беломестное С.Р., Братищев И.В., Вученович Ю.Д., Краснопольский В.И., Куликов А.В., Левит А.Л., Петрухин В.А., Пырегов А.В., Серов В.Н., Сидорова И.С., Филиппов О.С., Ходжаева З.С., Холин А.М., Шешко Е.Л., Шифман Е.М., Шмаков Р.Г. Гипертензивные расстройства во время беременности, в родах и послеродовом периоде. Преэклампсия, эклампсия. Клинические рекомендации. М.; 2016.
  2. Шалина Р.И., Коновалова О.В., Нормантович Т.О. Возможности прогнозирования и профилактики гестоза в I. триместре беременности. Практическая медицина. 2010; 4: 38-43.
  3. Шалина Р.И., Коновалова О.В., Нормантович Т.О., Лебедее Е.В. Прогнозирование гестоза в первом триместре беременности: миф или реальность? Вопросы гинекологии, акушерства и перинатологии. 2010; 9(4): 82-7.
  4. National Institute for Health and Care Excellence. Hypertension in pregnancy: diagnosis and management. NICE guideline. 25 June 2019. Available at: www. nice.org.uk/guidance/ng133.
  5. ACOG Practice Bulletin No. 202: Gestational hypertension and preeclampsia. Obstet. Gynecol. 2019; 133(1): e1-25. https//dx.doi.org/10.1097/ AOG.0000000000003018.
  6. Poon L.C., Stratieva V., Piras S., Piri S., Nicolaides K.H. Hypertensive disorders in pregnancy: combined screening by uterine artery Doppler, blood pressure and serum PAPP-A at 11-13 weeks. Prenat. Diagn. 2010; 30(3): 216-23. https// dx.doi.org/10.1002/pd.2440.
  7. O'Gorman N., Wright D., Poon L.C., Rolnik D.L., Syngelaki A., de Alvarado M. et al. Multicenter screening for pre-eclampsia by maternal factors and biomarkers at 11-13 weeks' gestation: comparison with NICE guidelines and ACOG recommendations. Ultrasound Obstet. Gynecol. 2017; 49(6): 756-60. https//dx.doi.org/10.1002/uog.17455.
  8. Bose P., Black S., Kadyrov M., Weissenborn U., Neulen J., Regan L. et al. Heparin and aspirin attenuate placental apoptosis in vitro: implications for early pregnancy failure. Am. J. Obstet. Gynecol.2005; 192(1): 23-30.
  9. Navaratnam K., Alfirevic A., Jorgensen A., Alfirevic Z. Aspirin non-responsiveness in pregnant women at high-risk of pre-eclampsia. Eur. J. Obstet. Gynecol. Reprod. Biol. 2018; 221: 144-50. https://dx.doi.org/10.1016/j.ejogrb.2017.12.052.
  10. Wojtowicz A., Undas A., Huras H., Musial J., Rytlewski K., Reron A. et al. Aspirin resistance may be associated with adverse pregnancy outcomes. Neuroendocrinol. Lett. 2011; 32(3): 334-9.
  11. Rolnik D.L., Wright D., Poon L.C., O'Gorman N., Syngelaki A., de Paco Matallana C. et al. Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia. N. Engl. J. Med. 2017; 377(7): 613-22. https//dx.doi. org/10.1056/NEJMoa1704559.
  12. Медведев М.В., Алтынник Н.А., Князев П.В. Прогноз и предупреждение преэклампсии и замедления роста плода в 11-14 недель беременности: анализ 1001 наблюдения. Пренатальная диагностика. 2018; 17(3): 261-6. [Medvedev M.V., Altynnik N.A., Knyazev P.V. Prediction and prevention of preeclampsia and fetal growth restriction at 11-14 weeks of gestation: analysis of 1001 cases. Prenat. Diag. 2018; 17(3): 261-6. (in Russian)]. https//dx.doi. org/10.21516/2413-1458-2018-17-3-261-266.
  13. O'Gorman N., Wright D., Syngelaki A., Akolekar R., Wright A., Poon L.C. et al. Competing risks model in screening for preeclampsia by maternal factors and biomarkers at 11-13 weeks gestation. Am. J. Obstet. Gynecol. 2016; 214(1): 103. e1-103. e12. https//dx.doi.org/10.1016/j.ajog.2015.08.034.
  14. Макацария А.Д., Бреннер Б., Бицадзе В.О., Акиньшина С.В. Системный венозный и артериальный тромбоэмболизм в акушерско-гинекологической практике. М.: МИА; 2016: 283-4.
  15. First Trimester Prediction and Prevention of Preterm Preeclampsia. A transcript of Professor Kypros Nicolaides’s webcast, broadcast on April 24th 2018.
  16. Poon L.C.Y., Staboulidou I., Maiz N., Plasencia W. Hypertensive disorders in pregnancy: screening by uterine artery Doppler at 11-13 weeks. Ultrasound Obstet. Gynecol. 2009; 34(5): 142-8. https//dx.doi.org/10.1002/ uog.7439.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2020 Bionika Media

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies