Hormonal sensitivity of endometrial polyps and the efficiency of LNG-IUD as a method of their secondary prevention


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Abstract

Background. The Endometrial polyp’s (EP) recurrence rate reaches 20%, that indicates the necessity of new pathogenically oriented prevention method’s development. The aim of the study was to analyze the expression of sex steroids’ isoforms in EP and the eff iciency of LNG-IUD as a method of their secondary prevention. Materials and methods. 130 patients with EP were recruited for US-monitoring during a year after polypectomy, 27 of them were (treated) with LNG-IUD. 20 samples of EP, 20 - normal endometrium and 15 biopsies after LNG-IUD exposure were enrolled for assessing the expression of estrogen (ER-а, ER-в) and progesterone (PR-A, PR-B) receptor’s isoforms. Results. Expression of ER-в and PR-A in EP, which inhibit endometrial growth, was decreased, while PR-B’s expression, inducing proliferation - increased. The EP’s recurrence rate reached 17.1%, while in the LNG-IUD group no relapses were observed due to suppression of all ER and PR isoforms. Conclusions. The imbalance of ER and PR isoforms can lead to EP formation, indicate their hormone sensitivity and the validity of LNG-IUD as a method of their secondary prevention.

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About the authors

Galina E. Chernukha

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: g_chernukha@oparina4.ru
M.D., professor

Alexandra V. Asaturova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_asaturova@oparina4.ru
Ph.D., senior scientific researcher

Ilya A. Ivanov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: doctor.i.ivanov@yandex.ru
postgraduate student

Alexey A. Korshunov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_korshunov@oparina4.ru
gynecologist

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