Role of CaV1.2 calcium channel expression in the development of some pathological conditions in obstetrics and gynecology


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Abstract

Studying of the expression of CaV1.2 calcium channels is relevant in the practice of an obstetrician/gynecologist, as well as in therapy, psychiatry, neonatology, and gynecologic oncology. The clinical effects of calcium channel disorders depend on the level of expression of the CACNA1C gene, its penetrance and can determine a number of clinical conditions with the formation of a sarcopenic phenotype: asthenic hypotrophic body type (30%), muscle asthenia, childhood-onset refractive errors (22.2%), arterial hypotension (60%), functional isthmico-cervical insufficiency during pregnancy (23%), oxytocia and accelerated labor (37.6%), a tendency towards constipation (55%), varicosity (39.5%), pelvic floor protrusion and relaxation (50%), apical genital prolapse (60%), joint hypermobility (48.8%), grade 2 scoliosis (33 %), grade 3 platypodia (73.8%), hypotonic bowel dysfunction (50- 60%) A relationship was shown between the lower expression level of CaV1.2 calcium channels in the round ligament of the uterus in patients with genital prolapse and the incidence of incomplete right bundle branch block (33%), ST segment elevations (15%), cardiac structural abnormalities (88%), and apical genital prolapse (60%) in young patients. Conclusion. Studying the expression level of the a-1 subunit of the CaV1.2 voltage-dependent calcium channel and the level of protein expression in smooth muscle tissue will help not only to explain the etiopathogenetic mechanisms of a number of pathological conditions in obstetrics, gynecology, and neonatology (miscarriage, hypertension during pregnancy, childbirth and postpartum; a sarcopenic phenotype in pregnant women, congenital heart rhythm disturbances, cardiomyopathy, Brugada syndrome in newborns, etc.), as well as in operative gynecology and general surgery, but also to apply a personalized approach to choosing a method for treatment, prevention, and rehabilitation.

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About the authors

Tatiana Yu. Smolnova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: smoltat@list.ru
MD., senior associate of Surgery department

Aleksey M. Krasnyi

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: alexred@list.ru
PhD, the head of the Cytology laboratory

Alsu A. Sadekova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_sadekova@oparina4.ru
PhD, scientific researcher of the Cytology laboratory

Vladimir D. Chuprynin

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: v_chuprynin@oparina4.ru
PhD/Med, head of the Surgery department

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