Endometrial expression of tyrosine kinase receptor (EphA2) in patients with deep infiltrating endometriosis


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Abstract

Objective. To assess the endometrial expression pattern of EphA2 receptor in healthy women and in ectopic epithelial cells in the presence of deep infiltrating endometriosis. Subjects and methods. EphA2 expression in the ectopic endometrium during the different phases of the menstrual cycle was comparatively examined in women with endometriosis or endometrial adenocarcinoma and in healthy women. Results. Immunochemical studies showed that EphA2 was present in the epithelial cells of the normal endometrium in the proliferative phase and was practically absent in the secretory phase. The staining intensity was statistically significantly higher in the epithelial cells of the infiltrating ectopic endometrium than that in those of the normal endometrium in the proliferative phase and was comparable to that of EphA2 expression in endometrial cancer cells. Conclusion. The study showed EphA2 overexpression in the epithelial cells of the infiltrating ectopic endometrium. Thus, in addition to its diagnostic value, modulation of the activity of these receptors in endometriosis can serve as a therapeutic target.

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About the authors

Shahnoza K. Muftaidinova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Vladimir Dmitrievich Chuprynin

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: v_chuprynin@oparina4.ru

Nafisa M. Faizullina

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: nafisa05@inbox.ru

Natalya A. Buralkina

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: n_buralkina@oparina4.ru

Aleksandr I. Shchegolev

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: ashegolev@oparina4.ru

Leonod Z. Faizullin

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: l_faizullin@oparina4.ru

Dmitriy L. Ovodenko

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: d_ovodenko@oparina4.ru

Aleksandra V. Asaturova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_asaturova@oparina4.ru

Vladimir N. Serov

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: v_serov@oparina4.ru

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