The role of maternal gut microbiota in spontaneous preterm birth


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Abstract

Objective. To study the potential correlation between maternal gut microbiota and preterm labor. Materials and methods. A prospective case control study included 40 puerperas. The patients were divided into two groups: group I consisted of women who had spontaneous preterm birth; group II included healthy women who had full-term births. The study of the gut microbiota was carried out using a culture method. Results. The gut microbiota of patients in both groups was presented mainly by the microorganisms of Bifidobacterium spp., Lactobacillus spp., Bacteroides spp., Enterococcus and Escherichia spp. In group I, patients who gave birth prematurely had more frequently opportunistic pathogens of facultative anaerobic origin, namely Staphylococcus aureus (p=0.0365) and/or Klebsiella pneumoniae (p=0.0217); they had a higher logarithmic value of colony-forming units (CFU) compared to the group of patients who had full-term births; patients of group I also showed a poorer growth of obligate anaerobes - Bacteroides spp. (p=0.0416); the results were statistically significant. Conclusion. The gut microbiota is likely to play a role in spontaneous preterm birth.

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About the authors

Ksenia A. Gorina

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: k_gorina@oparina4.ru
Junior researcher at the Department of Pathology of Pregnancy

Zulfiya S. Khodzhaeva

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: zkhodjaeva@mail.ru
M.D., Professor, Deputy Director for Research of Obstetrics Instituteof the Institution (Department of Obstetrics)

Vera V. Muravieva

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: v_muravieva@oparina4.ru
Ph.D. in Biological sciences, senior research officer Laboratory Microbiology

Kamilla T. Muminova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: k_muminova@oparina4.ru
Ph.D., Junior researcher at the Department of Pathology of Pregnancy

Andrew Ye. Donnikov

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: a_donnikov@oparina4.ru
Ph.D., Head of the Laboratory of Molecular Genetic Methods

Tatyana V. Priputnevich

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: priputl@gmail.com
M.D., Head of the Departament of Microbiology and Clinical Pharmacology

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