Polycystic ovary syndrome: computer program-assisted diagnosis based on clinical and anamnestic factors and hormonal and ultrasound markers


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Objective. To develop a computer program for the diagnosis of polycystic ovary syndrome (PCOS) in reproductive-aged women. Subjects and methods. The investigation enrolled 200 women aged 18 to 35 years, who were examined using clinical, anamnestic, laboratory, ultrasound, and statistical studies: Group 1 consisted of100 women with PCOS; Group 2 included 100 women without PCOS. Results. Statistically significant differences were found between the main indicators characterizing the ovarian reserve in reproductive-aged women with PCOS and in healthy ones. Based on the obtained information base, a computer program was developed using the logistic regression method for the diagnosis of factors and the identification of diagnostic markers for PCOS; the program was tested using an independent sample. The sensitivity and specificity of this method to diagnose PCOS were 70.9% and 75.7%, respectively. The computer program “Clinical, anamnestic, laboratory, and ultrasound diagnosis of PCOS” was developed and registered (State Registration Certificate for Computer Program No. 2019662249; the state registration date in the Computer Programs Registry was September 9, 2019 in the Federal Service for Intellectual Property, Moscow). Conclusion. The program “Clinical, anamnestic, laboratory, and ultrasound diagnosis of PCOS”, which is based on the identification of clinical and anamnestic factors, laboratory and ultrasound markers, can be recommended for routine use for the diagnosis of PCOS and a more differentiated approach to implementing therapeutic measures.

Full Text

Restricted Access

About the authors

Angelika Yu. Beglova

Kemerovo State Medical University

Email: angelik-i986@mail.ru

Svetlana I. Elgina

Kemerovo State Medical University

Email: elginas.i@mail.ru

References

  1. Соснова Е.А. Синдром поликистозных яичников. Архив акушерства и гинекологии им. В.Ф. Снегирева. 2016; 3 (И): 116-29. doi: 10.18821/2313-8726-2016-3-3-116-129
  2. Назаренко ТА., Мишиева Н.Г. Бесплодие и возраст: пути решения проблемы. 2-е изд. М.: МЕДпресс-информ, 2014. 216 с.
  3. De Leo V., Musacchio M.C., Cappelli V., Massaro M.G., Morgante G., Petraglia F. Genetic, hormonal and metabolic aspects of PCOS: an6 5u,p0date. Reprod Biol Endocrinol. 2016; 14(1): 38. doi: 10.1186/s12958-016-0173-x.
  4. Dumesic D.A., Oberfield S.E., Stener-Victorin E., Marshall J.S., Legro R.S. Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome. Endocr Rev. 2015; 36(5): 487-525. doi: 10.1210/er.2015-1018.
  5. Синдром поликистозных яичников в репродуктивном возрасте (современные подходы к диагностике и лечению): клинические рекомендации (протокол лечения). Минздрав Российской Федерации. М., 2015. 22 с.
  6. Vembu R., Reddy N.S. Polycystic Ovary Syndrome (PCOS), Diagnostic Criteria and AMH. Endocr Rev. 2017; 18(1): 17-21. doi: 10.22034/APJCP.2017.18.1.17
  7. Гоготадзе И.Н., Федорова А.И. Синдром поликистозных яичников в практике подросткового гинеколога: возможности профилактики, принципы терапии. Гинекология. 2017; 19(2): 23-7.
  8. Дубровина С.О. Синдром поликистозных яичников: современный обзор. Гинекология. 2016; 18(5): 14-7. Dubrovina S.O. Polycystic ovarian syndrome: a modern overview. Gynecology. 2016; 18 (5): 14-19. (In Russ.)].
  9. Назаренко Е.А. Стимуляция функции яичников. 4-е изд. М.: МЕДпресс-информ, 2013. 38-46.
  10. Хащенко Е.П., Уварова Е.В., Мамедова Ф.Ш. Фенотипические особенности синдрома поликистозных яичников у девочек подросткового возраста. Журнал Репродуктивное здоровье детей и подростков. 2017; 1: 37-50.
  11. Elgina S., Artymuk N., beglova A. Indicators of an ovarian reserve in women of early reproductive age with PCOS depending on the phenotype. Hormone Molecular Biology and Clinical Investigation.2019: 39(3): 20180081. doi: https:// doi.org/10.1515/hmbci-2018-0081
  12. Lizneva D., Suturina L., Walker W., Brakta S., Gavrilova-Jordan L., Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Endocr Rev. 2016; 106(1): 6-15. doi: 10.1016/j.fertnstert. 2016.05.003
  13. Romualdi D. The role of anti-Mullerian hormone in the characterization of the different polycystic ovary syndrome phenotypes. ReprodSci. 2016; 23 (5): 655-6. doi: 10.1177/1933719115611751.
  14. Yildiz B.O. Polycystic ovary syndrome: is obesity a symptom. Women’s Health. 2013; 9(6): 505-7. doi: 10.2217/whe.13.53.
  15. Conway G., Dewailly D., Diamanti-Kandarakis E., Escobar-Morreale H.F., Franks S., GambineriA, Kelestimur F., Macut D., Micic D., Pasquali R., Pfeifer M., Pignatelli D., Pugeat M., Yildiz B.O.; ESE PCOS Special Interest Group. The polycystic ovary syndrome: a position statement from the European Society of Endocrinology. Eur J. Endocrinol. 2014; 171(4):P1-29. doi: 10.1530/EJE-14-0253.
  16. Legro R.S., Arslanian S.A., Ehrmann D.A., Hoeger K.M., Murad M.H., Pasquali R., Welt C.K. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism. 2013; 98 (12): 4565-92. doi: 10.1210/jc.2013-2350 Поступила 12.11.2019 Принята в печать 29.11.2019 Received 12.11.2019 Accepted 29.11.2019
  17. Bani Mohammad M., Majdi Seghinsara A. Polycystic Ovary Syndrome (PCOS), Diagnostic Criteria and AMH. Endocr Rev. 2017; 18(1): 17-21. doi: 10.22034/ APJCP.2017.18.1.17

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies