Amniotic fluid composition in pregnant women at high risk of preterm birth


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Abstract

Aim. To investigate the composition of the amniotic fluid in pregnant women at high risk of preterm birth. Materials and methods. The study analyzed the composition of the amniotic fluid of 46 pregnant women aged 19 to 40 years who were at a high risk of preterm birth. The patients were categorized into two groups based on pregnancy outcomes, including 12 women with preterm birth (group I) and 34 women who had a full-term delivery (group 2). Amniotic fluid was collected using diagnostic transabdominal amniocentesis. The amniotic fluid analysis was carried out using hematological and biochemical automatic analyzers. Results. The composition of the amniotic fluid differed statistically significantly between the study groups regarding the number of lamellar bodies (p=0.048), neutrophils (p=0.048), and total protein concentration (p=0.049). The presence of signs of an inflammatory process was associated with greater fetal lung maturity (r=0.33, p=0.046). Statistically significant correlations were found between the number of lamellar bodies and the cerebellum size (r=0.38, p=0.04), femur length (r=0.32, p=0.04), resistance index in the fetal MCA (r=-0.32, p=0.04). Conclusion. Laboratory analysis of the amniotic fluid composition allows the detection of intra-amniotic inflammation and determination of the degree of fetal lung maturity, which is essential information for optimizing obstetric management.

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About the authors

Zulfiya S. Khodzhaeva

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: zkhodjaeva@mail.ru
M.D., Professor, Deputy Director for Research of Obstetrics Instituteof the Institution (Department of Obstetrics)

Ksenia A. Gorina

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: k_gorina@oparina4.ru
Junior researcher at the Department of Pathology of Pregnancy

Kamilla T. Muminova

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: k_muminova@oparina4.ru
Ph.D., Junior researcher at the Department of Pathology of Pregnancy

Tatyana Yu. Ivanets

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: t_ivanets@oparina4.ru
Dr.Med.Sci., Head of the Clinical Diagnostic Laboratory

Yulia V. Kessler

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: y_kessler@oparina4.ru
Clinical Pathologist at the Biochemistry Laboratory

Tatyana V. Priputnevich

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: priputl@gmail.com
M.D., Head of the Departament of Microbiology and Clinical Pharmacology

Dmitry M. Belousov

V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of Minzdrav of Russia

Email: d_belousov@oparina4.ru
Diagnostic Medical Sonographer

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