Wolffian duct cell tumor

Background. Wolffian duct cell tumor is a little studied and rarely found neoplasm. No more than 100 cases of this tumor have been described in the world literature. The tumor develops due to disorders in the process of embryogenesis. In the female fetus, the Wolffian ducts are known to undergo involution, whereas the low level of anti-Mullerian hormone allows the Mullerian duct to develop. However, when differentiation of female genital organs is impaired, the fetus develops neoplasms from the rudiments of the Wolffian duct. According to the WHO Classification of Tumors of Female Reproductive Organs, the neoplasm is presently called Wolffian duct cell tumor and is generally detected in the broad ligament of the uterus, fallopian tubes, mesosalpinx, and ovary. There have been single case reports of retroperitoneal Wolffian duct cell tumor in the lateral channel of the abdominal cavity. There are no clinical practice guidelines for the treatment of Wolffian duct cell tumor; therefore, a description of clinical cases of this rare tumor is of interest. Case report. This paper describes a clinical case of a tumor of Wolffian origin concurrent with stage IB1 cervical cancer in a 45-year-old woman. It shows the features of clinical and instrumental examinations. A morphological study plays a key role in the diagnosis of an ovarian tumor. An immunohistochemical study is a specified diagnostic method, which reveals no expression with antibodies to Inhibin, Vimentin, Calretinin, Chromogranin, CD-99, CD-10, WT-1, and estrogen receptors. The tumor cells focally expressed SK-7, EMA, andp-53, which suggested that the tumors of Wolffian origin are immunologically non-specific. The data available in the literature show that no expression with anti-CD-56 antibodies may indicate the benign course of the tumor. Conclusion. The clinical case under discussion shows that in the morphological pattern of the tumor, there are no necrotic areas or signs of invasive growth into the capsule; a low mitotic activity was found. In this connection, the tumor was regarded as apparently benign. It is recommended that the patient be followed up.

Wolffian duct, Wolffian duct cell tumor, immunohistochemcal study, ovarian tumor