Innovative laser technologies in the diagnosis and treatment of the endometrium of concern in reproductive medicine


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Abstract

Objective. To enhance the efficiency of diagnosis and treatment of endometrial pathology (EP) in assisted reproductive technology (ART) programs. Patients and methods. A total of 449 patients aged 28 to 52 years were examined. All had several unsuccessful in vitro fertilization (IVF) attempts and EP. Optical spectroscopy was a special method for diagnosing the morphological and functional state of the endometrium. Laser phototherapy was a method for endometrial rehabilitation. Results. The women with ineffective IVF and PE were found to have hypoxia and impairments in proliferation, structuredness, and metabolism in the endometrium. Laser phototherapy increased oxygenation up to the normal physiological level (in 34.2 and 38.5% of women in menstrual cycle phases I and II, respectively). Pregnancy occurred in 68.4% of women. Conclusion. Integrated optical spectroscopy has shown to be highly effective in diagnosing the functional parameters of the endometrium, which determine its ability to implant. Laser phototherapy is a highly effective method for the rehabilitation of EP.

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About the authors

V. M Zuev

ART-ECO Reproductive Health Clinic; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

Email: vlzuev@bk.ru
professor, Department of Obstetrics and Gynecology 8 Trubetskaya str., Moscow, 119048, Russian Federation

E. A Kalinina

ART-ECO Reproductive Health Clinic

Email: kalinina@art-ivf.ru
MD., the General Director of the clinic of reproductive health Moscow, 119435, Russian Federation

V. I Kukushkin

Institute of Solid State Physics, Russian Academy of Sciences

Email: kukushvi@mail.ru
2 Akad. Osip’yan str., Chernogolovka, 142432, Russian Federation

T. A Dzhibladze

I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

Email: djiba@bk.ru
Professor, Department of Obstetrics and Gynecology 8 Trubetskaya str., Moscow, 119991, Russian Federation

E. V Zharov

Central Clinical Hospital, Russian Academy of Sciences

Email: zharov@ag-info.ru
Professor 1A Litovsky bulvar, Moscow, 117593, Russian Federation

M. O Montanino

Department of Obstetrics, Gynecology, and Reproductive Medicine, Santo Spirito Hospital

Email: mario.montanino@artemisia.it
PhD LungotevereinSaxia 1, 00193, Rome, Italy

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