Retrieval of testicular spermatozoa in azoospermic men after cancer treatment: ten years’ experience


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Objective. To evaluate the effectiveness of results from open microsurgical testicular extraction (m-TESE) biopsy in azoospermk patients after chemoradiotherapy. Patients and methods. Micro-TESE biopsy was carried out in 79 azoospermk patients. Results. Mobile, morphologically normal spermatozoa suitable for assisted reproductive technology (ART) programs were detected in 18 (23%) patients and cryopreserved; morphologically altered spermatozoa unsuitable for cryopreservation and ART programs were found in 4 (5%) patients; no spermatozoa were seen in 57(72%). Conclusion. Open m-TESE biopsy is an effective method for retrieving sperm in azoospermicpatients after chemo-radiotherapy

Full Text

Restricted Access

About the authors

S. Kh Izhbaev

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: izhbaev-sergei@mail.ru
Cand. Med. Sci. 4, Academician Oparin St., Moscow 117997, Russia

R. I Ovchinnikov

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: r_ovchinnikov@oparina4.ru
Cand. Med. Sci. 4, Academician Oparin St., Moscow 117997, Russia

S. I Gamidov

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

Email: s_gamidov@oparina4.ru
MD; Head, Department of Andrology and Urology, Professor, Department of Obstetrics, Gynecology, Perinatology, and Reproductology, Institute of Postgraduate Education 4, Academician Oparin St., Moscow 117997, Russia

A. Y.U. Popova

Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia

Email: a_popova@oparina4.ru
Cand. Med. Sci.; Senior Researcher, Department of Andrology and Urology, Department of Obstetrics, Gynecology, Perinatology, and Reproductology, Institute of Postgraduate Education 4, Academician Oparin St., Moscow 117997, Russia

References

  1. Gertosio C, Magistrali M, Musso P., Meazza C., Bozzola M. Fertility preservation in pediatric oncology patients: new perspectives. J. Adolesc. Young Adult Oncol. 2018; 7(3): 263-9. https://dx/doi.org/10.1089/jayao.2017.0117.
  2. Jegaden M, Bouhnik A.D., Preau M., Bendiane M.K., Peretti-Wate l.P., Mancini J., Courbiere B. Fertility status perception, fertility preservation and desire to have children in cancer survivors: French VICAN survey. Future Sci. OA. 2018; 4(10): FSO343. https://dx/doi.o/10.4155/fsoa-2018-0018.
  3. Lopategui D.M., Ibrahim E, Aballa T.C., Brackett N.L., Yechieli R., Barredo J.C., Ramasamy R. Effect of a formal oncofertility program on fertility preservation rates-first year experience. Transl. Androl. Urol. 2018; 7(Suppl. 3): S271-https://dx/doi.org/10.21037/tau.2018.04.24.
  4. Beaud H., Tremblay A.R., Chan P.T.K., Delbes G. Sperm DNA damage in cancer patients. Adv. Exp. Med. Biol. 2019; 1166: 189-203. https:// dx/doi.org/10.1007/978-3-030-21664-1_11.
  5. Stahl O., Boyd H.A., Giwercman A., Lindholm M., Jensen A., Kj&r S.K. et al. Risk of birth abnormalities in the offspring of men with a history of cancer: a cohort study using Danish and Swedish national registries. J. Natl. Cancer Inst. 2011; 103(5): 398-406. https://dx/doi.org/10.1093/jnci/djq550.
  6. Frias S., Ramos S., Salas C., Molina B., Sanchez S., Rivera-Luna R. Nonclonal chromosome aberrations and genome chaos in somatic and germ cells from patients and survivors of Hodgkin lymphoma. Genes (Basel). 2019; 10(1). pii: E37. https://dx/doi.org/10.3390/genes10010037.
  7. BeaudH., Albert O., Robaire B., Rousseau M.C., Chan P.T.K., Delbes G. Sperm DNA integrity in adult survivors of paediatric leukemia and lymphoma: A pilot study on the impact of age and type of treatment. PLoS One. 2019; 14(12): e0226262. https://dx/doi.org/10.1371/journal.pone.0226262.
  8. Furuhashi K., Ishikawa T., Hashimoto H., Yamada S., Ogata S., Mizusawa Y. et al. Onco-testicular sperm extraction: testicular sperm extraction in azoospermic and very severely oligozoospermic cancer patients. Andrologia. 2013; 45(2): 10710. https://dx/doi.org/10.1111/j.1439-0272.2012.01319.x.
  9. Tsutsumi S., Kawahara T., Takeshima T., Chiba S., Uemura K., Otani M. et al. Onco-testicular sperm extraction (onco-TESE) for bilateral testicular tumors: two case reports. J. Med. Case Rep. 2017; 11(1): 139. https:// dx/doi.org/10.1186/s13256-017-1303-6.
  10. Roque M., Sampaio M., Salles P.G., Geber S. Onco-testicular sperm extraction: birth of a healthy baby after fertility preservation in synchronous bilateral testi cular cancer and azoospermia. Andrologia. 2015; 47(4): 482-5. https://dx/doi. org/10.1111/and.12292.
  11. Haddad N., Al-Rabeeah K., Onerheim R., Zini A. Is ex vivo microdissection testic ular sperm extraction indicated for infertile men undergoing radical orchiectomy for testicular cancer? Case report and literature review. Fertil. Steril. 2014; 101(4): 956-9. https://dx/doi.org/10.1016/j.fertnstert.2013.12.052.
  12. Carrasquillo R., Savio L.F., Venkatramani V., Parekh D., Ramasamy R. Using microscope for onco-testicular sperm extraction for bilateral testis tumors. Fertil. Steril. 2018; 109(4): 745. https://dx/doi.org/10.1016/j.fertnstert.2018.01.016.
  13. Shiraishi K., Matsuyama H. Microdissection testicular sperm extraction and salvage hormonal treatment in patients with postchemotherapy azoospermia. Urology. 2014; 83(1): 100- 6. https://dx/doi.org/10.1016/j.urology.2013.08.043.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies