Application of assisted reproductive technology programs in a female patient with systemic lupus erythematosus and antiphospholipid syndrome


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Abstract

Background. Patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) often face the problems related to their reproductive function; in this connection many patients undergo assisted reproductive technology (ART) programs. However, the challenges in implementing the ARTprograms in this group of patients include diminished ovarian reserve due to the treatment received, as well as the risk of an exacerbation of the underlying disease and thrombosis. Case report. This describes a case of a successfully implemented in vitro fertilization (IVF) program, followed by embryo cryopreservation in the patient with severe SLE and APS and a family obstetric/gynecological history. Conclusion. The authors describe the stages of the IVF program in the modified clinical and embryological protocol for ovarian stimulation with gonadotropin-releasing hormone antagonists and subsequent embryo cryopreservation, as well as the measures to prevent complications of the underlying disease.

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About the authors

N. M Kosheleva

A.A. Nasonova Research Institute of Rheumatology, Ministry of Science and Higher Education of Russia

Email: nadkosheleva@yandex.ru
scientific researcher of the Laboratory of Vascular Rheumatology 34A, Kashirskoye Shosse, Moscow, 115522, Russian Federation

S. G Perminova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: perisvet@list.ru
MD, PhD, Leading researcher of 1-st gynecology department 4, Oparina str., Moscow, 117997, Russian Federation

G. A Vlasova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: galinavlasova089@gmail.com
graduate student of 1-st gynecology department 4, Oparina str., Moscow, 117997, Russian Federation

A. O Kirillova

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia

Email: a_kozyreva@oparina4.ru
PhD, Senior 4, Oparina str., Moscow, 117997, Russian Federation. 18

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