CLINICAL COURSE, MATERNAL AND PERINATAL OUTCOMES OF 2019 NOVEL CORONAVIRUS INFECTIOUS DISEASE (COVID-19) IN PREGNANT WOMEN IN SIBERIA AND FAR EAST
- Authors: Belokrinitskaya T.E.1, Artymuk N.V.2, Filippov O.S.3, Frolova N.I.1
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Affiliations:
- Chita State Medical Academy, Ministry of Health of Russia
- Kemerovo State Medical University, Ministry of Health of Russia
- A.I.Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
- Issue: No 2 (2021)
- Pages: 48-54
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/249019
- DOI: https://doi.org/10.18565/aig.202L2.48-54
- ID: 249019
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Open Access
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Abstract
Aim. To assess the morbidity, clinical course, maternal and perinatal outcomes of COVID-19 in pregnant women in the Far Eastern and Siberian Federal Districts. Materials and methods. The latest information on COVID-19 in pregnant, parturient and puerperal women was analyzed. The data were presented by chief obstetricians-gynecologists of these Districts in the period from 11 March to 25 December 2020. Results. During the specified period, 8485 cases of COVID-19 were registered in pregnant, parturient and puerperal women. The rate of morbidity was 3 times higher among these women compared to the general population: 5933.2 versus 1960.8 per 100,000 people. In 27.4% of mothers, SARS-CoV-2 infection was asymptomatic; in 52.7% it was mild; in 16.6% - moderately severe, in 2.5% - severe and in 0.5% - very severe. Pregnant women were more often hospitalized and stayed in intensive care and anesthesiology units compared to patients in the general population (3.57% vs 2.24%, р<0.001), and invasive mechanical ventilation (IMV) was used less often (0.48% vs 1.05%, р<0.001). 27.97% (2373) of patients delivered their babies. Preterm delivery was in 18.3% of women, cesarean section - in 42.0%, operative vaginal delivery - in 0.2%. 12 mothers (0.14%) with COVID-19 died (mortality rate was 1.95% in the general population, р<0.001). Maternal mortality rate was 505.69per 100,000 live births. Perinatal losses were registered in 37cases (1.54%): stillbirths - 31 (1.29%), early neonatal mortality - 6 (0.25%). 148 (6.2%) cases of COVID-19(+) were detected in newborns. Conclusion. The incidence of COVID-19 in pregnant women in Siberia and Far East is higher than in general population, but the disease is characterized by lower demand for IMV and lower mortality rate. The rates of preterm delivery and cesarean section in patients with COVID-19 were higher than in the general population. Finding of the SARSCoV-2 RNA in newborns suggested vertical transmission of the infection.
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About the authors
Tatiana E. Belokrinitskaya
Chita State Medical Academy, Ministry of Health of Russia
Email: tanbell24@mail.ru
MD, PhD, Professor, Head of the Obstetrics and Gynecology Department 39a Gorky str., Chita, 672000, Russian Federation
Natalya V. Artymuk
Kemerovo State Medical University, Ministry of Health of Russia
Email: artymuk@gmail.com
MD, PhD, Professor, Head of the G.A. Ushakova Department of Obstetrics and Gynecology 22a Voroshilova str., Kemerovo, 650056, Russian Federation
Oleg S. Filippov
A.I.Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
Email: fllippovolsem@yandex.ru
MD, PhD, Professor, Professor of the Department of Obstetrics and Gynecology 3 Rakhmanovsky str., Moscow, 127994, Russian Federation
Nataly I. Frolova
Chita State Medical Academy, Ministry of Health of Russia
Email: taasyaa@mail.ru
MD, PhD, Associate Professor of the Department of Obstetrics and Gynecology of the Pediatric Faculty, Faculty of Continuing Education and Professional Retraining 39a Gorky str., Chita, 672000, Russian Federation
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