EFFECTIVENESS OF INTRAUTERINE ADMINISTRATION OF AUTOLOGOUS PLATELET-RICH PLASMA TO PREPARE "THIN" ENDOMETRIUM FOR THE DEFROSTED EMBRYO TRANSFER PROGRAM


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Abstract

Purpose. To identify the effectiveness of platelet-rich plasma (PRP) use for preparation of "thin" endometrium for cryopreservation programs. Materials and methods. A prospective study was conducted; the main group included 37 patients with "thin" endometrium, among whom embryo transfer cycles were repeatedly canceled due to insufficient endometrial thickness. Against the background of receiving cyclic hormone therapy (CGT), patients were administered intrauterine PRP on the 8-9, 10-11, and 12-13 days of the menstrual cycle. The control group included 17patients with "thin" endometrium who received only CGT. The thickness of endometrium was assessed by ultrasound examination of pelvic organs. The endometrial thickness over 7 mm was considered optimal for embryo transfer. Results. After the use of PRP, the endometrial thickness of more than 7 mm was in 18 (48.65%) patients, in the control group - in 8 patients (p=0.92). The average endometrial thickness in the main group on the day of embryo transfer was 7.79 mm, in the control group - 6.89 mm (p=0.02). The embryo transfer cycle was cancelled in 6 patients (16.22%) in the main group and in 13 (76.47%) in the control group (p<0.001). Embryo transfer was performed in 32 (86.49%) patients in the main group and in 4 (23.53%) in the control group. Pregnancy occurred in 16 patients (50%) in the main group and in none of the patients in the control group (p=0.58). Among these, 14 (43.75%) patients in the main group had a clinical pregnancy; 4 (28.57%) patients had spontaneous miscarriage, and in 2 (14.29%) patients live births were documented. Conclusion. With intrauterine administration of PRP in addition to CGT, there is a statistically significant increase in the thickness of the endometrium, the frequency of termination of the embryo transfer cycle decreases; nominally, pregnancy rate is higher in the main group, but the difference is not statistically significant.

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About the authors

Lana G. Dzhincharadze

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: lanachka@list.ru
graduate student of 1st Gynecology Department 117997, Russia, Moscow, Ac. Oparina str., 4

Aydar N. Abubakirov

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: nondoc555@yahoo.com
PhD, Head of 1st Gynecology Department 117997, Russia, Moscow, Ac. Oparina str., 4

Nona G. Mishieva

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: nondoc555@mail.ru
PhD, Senior researcher of 1st Gynecology Department 117997, Russia, Moscow, Ac. Oparina str., 4

Eteri M. Bakuridze

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: eteri.bakuridze@mail.ru
PhD, Head of clinical work, Department of Transfusiology and Extracorporeal Hemocorrection 117997, Russia, Moscow, Ac. Oparina str., 4

Oksana A. Bystrykh

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: o_bystrikh@oparina4.ru
PhD, Head of Department of Transfusion Immunology and the Preparation of Blood Components 117997, Russia, Moscow, Ac. Oparina str., 4

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