Brain damage in preterm babies associated with congenital pneumonia


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Abstract

Currently, thanks to advanced assisted reproductive technologies, as well as improvement of the quality of obstetric and neonatal care, the population of the babies born before 37 weeks of gestation continues to increase. Perinatal brain damage is manifested by disorders affecting the structure and functions of the central nervous system (CNS), and is one of the major factors that contribute to formation of a severe neurological disorder and disability in preterm babies. Intraventricular hemorrhage is the most common form of structural brain damage in premature babies. According to the published data, the incidence of intraventricular hemorrhage is inversely proportional to the gestational age of premature infants and ranges from 15% to 31%. Congenital pneumonia contributes to adverse neurological outcomes of perinatal disorders in preterm babies. Aim. To def ine the correlation between congenital pneumonia in preterm babies and the incidence and severity of hypoxic-hemorrhagic brain damage. Materials and methods. Prospective case-control study was conducted in the Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology. The study included 271 premature infants born at 28-36 weeks of gestational age in the period from January, 2017 to February, 2019. The infants were stratified into 2 groups: group 1(the main group) - the babies with the signs of congenital pneumonia (n=115); the group 2 (the comparison group) - the babies without these signs (n=156). Results. In group1 the incidence and severity of perinatal disorders of CNS in preterm babies with congenital pneumonia was higher than in the comparison group. Conclusion. According to the obtained data, congenital pneumonia in preterm babies increases the risk of hypoxic-hemorrhagic brain damage.

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About the authors

Ekaterina I. Artamkina

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University); Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: artamkina.e@gmail.com
PhD student, Department of Neonatology, N.F. Filatov Clinical Institute of Children’s Health

Dmitry N. Degtyarev

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University); Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: d_degtiarev@oparina4.ru
Dr.Med.Sci., Professor, Head of the Department of Neonatology, N.F. Filatov Clinical Institute of Children’s Health

Milana D. Kvekveskiri

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University); Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: milly_apsny@mail.ru
PhD student, Department of Neonatology, N.F. Filatov Clinical Institute of Children’s Health

Anna R. Kirtbaya

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University); Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: a_kirtbaya@oparina4.ru
Cand.Med.Sci., associate professor of the Department of Neonatology, N.F. Filatov Clinical Institute of Children’s Health

Dzhenneta Yu. Amirkhanova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: djenn@mail.ru
neurologist at the consultative pediatric department, pathology department of newborns and premature children, Institute of Neonatology and Pediatrics

Olga S. Beznoschenko

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: ospaa@yandex.ru
doctor of clinical diagnostics, Laboratory of clinical immunology, Institute of Neonatology and Pediatrics

Julia K. Bykova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: yulia.bykova@mail.ru,yu_bykova@oparina4.ru
Ph.D., researcher and doctor of the Department of Ultrasound Diagnostics in Neonatology and Pediatrics, Associate Professor, Department of Radiation Diagnostics of Children

Yulia M. Golubtsova

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University); Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: yugolubtsova@yandex.ru
Cand.Med.Sci., Associate Professor, Department of Neonatology, N.F. Filatov Clinical Institute of Children’s Health

Ekaterina N. Balashova

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: e_balashova@oparina4.ru
Cand.Med.Sci., leading researcher of the A.G. Antonov Intensive Care Unit and Intensive Care of Newborns

Oleg V. Ionov

I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University); Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: dr.ionov@hotmail.com,o_ionov@oparina4.ru
Cand.Med.Sci., Associate Professor, Department of Neonatology, N.F. Fil atov Clinical Institute of Children’s Health; Head of the A.G. Antonov Intensive Care Unit and Intensive Care of Newborns

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